Anti-diarrhoeal, anti ulcer and antimicrobial activities of leaves of Bougainvillea glabra Choisy

Authors

  • E EDWIN Department of Herbal Drug Research, B.R. Nahata College Pharmacy & Contract Research Center, Mandsaur – 458001, Madhya Pradesh, India.
  • E SHEEJA Department of Herbal Drug Research, B.R. Nahata College Pharmacy & Contract Research Center, Mandsaur – 458001, Madhya Pradesh, India.
  • E TOPPO Department of Herbal Drug Research, B.R. Nahata College Pharmacy & Contract Research Center, Mandsaur – 458001, Madhya Pradesh, India.
  • V TIWARI Department of Herbal Drug Research, B.R. Nahata College Pharmacy & Contract Research Center, Mandsaur – 458001, Madhya Pradesh, India.
  • KR DUTT Department of Herbal Drug Research, B.R. Nahata College Pharmacy & Contract Research Center, Mandsaur – 458001, Madhya Pradesh, India.

Keywords:

Anti-diarrhoeal, Antimicrobial, Antiulcer, Bougainvillea glabra

Abstract

In order to scientifi cally appraise some of the folkloric uses of Bougainvillea glabra Choisy, the present study wasundertaken to examine the anti-diarrhoeal, antiulcer and antimicrobial activities of acetone, ethanolic and aqueousextract of leaves. Anti-diarrhoeal activity was tested in Castor oil induced diarrhea model using rats and Loperamide(3 mg/kg) was used as reference standard. The antiulcer activity was determined using alcohol induced ulcer modeland Omeprazole 10 mg/ kg was used as the standard. Both the studies were carried out at two dose level, 200 mg/kgand 400 mg/kg respectively. Antimicrobial activity was done by disc diffusion method at a concentration of 500 μg/discof the extract, using ofl oxacin (5 μg/disc) as the standard. The organisms used were Escherichia coli, Bacillus subtilis,Klebsiella pneumoniae, Staphylococcus aureus and Proteus vulgaris and the zone of inhibition was determined. Theplant extracts showed signifi cant anti-diarrhoeal, antiulcer and antimicrobial activities in the present study. The resultsobtained support the claim of local medical practitioners.

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Published

2007-06-20

How to Cite

1.
EDWIN E, SHEEJA E, TOPPO E, TIWARI V, DUTT K. Anti-diarrhoeal, anti ulcer and antimicrobial activities of leaves of Bougainvillea glabra Choisy. Ars Pharm [Internet]. 2007 Jun. 20 [cited 2024 Dec. 3];48(2):135-44. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4981

Issue

Vol. 48 No. 2 (2007)

Section

Original Articles

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