Optimization of Gastroretentive System for Oral Controlled Delivery of Cinnarizine Using Response Surface Methodology

Authors

  • HN SHIVAKUMAR Department of Pharmaceutical Technology, K.L.E.S College of Pharmacy, Rajajinagar 2nd Block, Bangalore, India
  • BG DESAI Department of Pharmaceutical Technology, K.L.E.S College of Pharmacy, Rajajinagar 2nd Block, Bangalore, India
  • M PATEL Department of Pharmaceutical Technology, K.L.E.S College of Pharmacy, Rajajinagar 2nd Block, Bangalore, India

Keywords:

Cinnarizine, Effervescent, Floating Drug Delivery, Gastroretentive, Hydrophilic matrix

Abstract

A controlled release effervescent fl oating system is proposed for gastroretentive delivery of cinnarizine. A 33 box-behnkendesign was employed to produce controlled release fl oating tablets of cinnarizine by direct compression method. Theeffect of the formulation variables such as levels of HPMC K4M (X1), sodium bicarbonate (X2) and citric acid (X3) onthe tablet fl oating characteristics and drug release was studied. The response parameters like total fl oating time (TFT),release at the end of 10 h (Rel10), time taken for 50% of the drug to release (t50) and Korsemeyer and Peppas diffusionexponent (n) were analyzed using response surface methodology. The parameters were analyzed using the F test andmathematical models were generated for each response parameter using multiple linear regression analysis (MLRA)and analysis of variance (ANOVA). All the three formulation variables studied had a signifi cant effect (P < 0.05) on theTFT whereas the levels of HPMC K4M and citric acid signifi cantly infl uenced the drug release. Numerical optimizationemploying desirability approach was used to develop an optimized formulation by setting constraints on the dependentand independent variables. The optimized formulation showed 82.37 % drug release during the TFT of 8.5 h in a zeroorder fashion with a t50 of 5.30 h. The experimental values of the TFT, t50 and Rel10 were found to agree with thosepredicted by the mathematical models confi rming the fore casting ability of MLRA and ANOVA.

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Published

2007-04-20

How to Cite

1.
SHIVAKUMAR H, DESAI B, PATEL M. Optimization of Gastroretentive System for Oral Controlled Delivery of Cinnarizine Using Response Surface Methodology. Ars Pharm [Internet]. 2007 Apr. 20 [cited 2024 Jul. 22];48(1):55-81. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4978

Issue

Vol. 48 No. 1 (2007)

Section

Original Articles

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