Liposomal Triamcinolone acetonide: Infl uence of composition in performance and stability
Keywords:
Liposomes, Triamcinolone Acetonide, Biophase, VectorAbstract
In topical presentation, Triamcinolone acetonide, a steroidal anti-infl ammatory preparation, presents all the disadvantagesof corticotherapy. However, on incorporation into a liposomal drug delivery system, the effectiveness of each dosagewithin the area of its activity (dermis and epidermis) is prolonged, serving to reduce secondary side effects. For thisreason, an attempt has been made to standardize a method for the preparation of a multilaminar liposomal deliverysystem of triamcinolone acetonide and to assess how much of the drug could be encapsulated by the varying liposomalformulations tested and consequently, which of these would prove to be the most suitable. The addition of cholesterolto such formulations was found to improve stability. However, although such an addition was found to reduce levelsof encapsulation of the drug, these still remained suffi ciently high. In the assessment of stability, storage temperaturewas found to bear an infl uence. Liposomes kept under cold storage (4-6ºC) presented higher stability than samplesstored at room temperature.Downloads
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