Formulation and Evaluation of Matrix tablets of Ambroxol hydrochloride using Natural hydrophilic polymer

Authors

  • V PHANI Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam, Sivakasi – 626130, Tamil Nadu, India.
  • S SHANMUGANATHAN Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam, Sivakasi – 626130, Tamil Nadu, India.
  • S PALANICHAMY Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam, Sivakasi – 626130, Tamil Nadu, India.
  • A THANGA TIRUPATHI Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam, Sivakasi – 626130, Tamil Nadu, India.

Keywords:

Ambroxol hydrochloride, Matrix tablet, Sustained release, Xanthan gum

Abstract

Sustained release matrix tablets of ambroxol hydrochloride of different drug: polymer ratios, such as F-1(1:1), F-2(1:1.5) and F-3 (1:2). Xanthan gum was used as matrix former and microcrystalline cellulose was used as diluent.Granules were prepared and evaluated for loose bulk density, tapped density, compressibility index, hausners ratio andangle of repose. All the granules were lubricated and compressed using 9mm fl at-faced punches. Compressed tabletswere evaluated for uniformity of weight, content of active ingredient, friability, hardness and In-vitro dissolution. Allthe formulations showed compliance with Pharmacopoeial standards. F-3 showed the sustained release of drug for 12hours with 97.3% release and the release profi le was close to the marketed sample of ambroxol hydrochloride (A-MS)and Stability studies were performed as per ICH guide. The drug release follows zero order kinetics (0.9661) and themechanism was found to be diffusion coupled with erosion.

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Published

2008-12-20

How to Cite

1.
PHANI V, SHANMUGANATHAN S, PALANICHAMY S, THANGA TIRUPATHI A. Formulation and Evaluation of Matrix tablets of Ambroxol hydrochloride using Natural hydrophilic polymer. Ars Pharm [Internet]. 2008 Dec. 20 [cited 2024 Jul. 22];49(4):341-52. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4971

Issue

Vol. 49 No. 4 (2008)

Section

Original Articles

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