Effect of Alpha lipoic acid on cadmium induced oxidative damage on heart, Brain, kidney, liver and lung of rats

Authors

  • R PRABHU Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda-390 001, Gujarat, INDIA.
  • A UPAGANLAWAR Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda-390 001, Gujarat, INDIA.
  • R BALARAMAN Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda-390 001, Gujarat, INDIA.

Keywords:

Alpha lipoic acid, Antioxidant, Cadmium, Lipid peroxidation

Abstract

This study investigated the protective effect of alpha lipoic acid (ALA) on cadmium induced oxidative damage in rats.Cadmium (100ppm) fed to normal rats resulted in signifi cant increase in the level of serum glutamate oxaloacetatetransaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and Alkaline Phosphatase (ALP). Animalsexposed to cadmium also showed a signifi cant increase in level of lipid peroxidation (LPO) and decreased levels of reducedglutathione (GSH), superoxide dismutase (SOD) , catalase (CAT) and membrane bound ATPases (Na+K+ATPase,Ca2+ATPase and Mg2+ATPase) in brain, lung, kidney, liver and heart as compared to control group. Co administrationof ALA (25mg/kg/day, i.p.) along with cadmium for thirty days signifi cantly decreased the levels of SGOT, SGPT andAlkaline Phosphatase in the serum to near normal levels. ALA also reduced the level of MDA and increased the levels ofSOD, CAT, GSH and membrane bound ATPases in all the organs of the animals treated with cadmium to near normallevels. This study demonstrates the free radical damage caused by administration of cadmium on different organs andthe antioxidant effect of ALA which protects the organs from this damage when it is given along with cadmium.

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Published

2008-12-20

How to Cite

1.
PRABHU R, UPAGANLAWAR A, BALARAMAN R. Effect of Alpha lipoic acid on cadmium induced oxidative damage on heart, Brain, kidney, liver and lung of rats. Ars Pharm [Internet]. 2008 Dec. 20 [cited 2024 Jul. 22];49(4):293-307. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4968

Issue

Vol. 49 No. 4 (2008)

Section

Original Articles

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