Cytotoxicity of 1-O-undecylglycerol in human breast cells by Real Time Cell Analysis
DOI:
https://doi.org/10.30827/ars.v57i2.4963Keywords:
alkylglycerols, RTCA, MCF-7, 184B5Abstract
Aim: To study the effect of 1-O-undecylglycerol on the proliferation of human breast cancer cells MCF-7 and 184B5 normal breast cells.
Methods: Real time following of both cell lines was performed, by Real Time Cell Analyzer. Appropriated cell density was selected, and cells were treated with two concentrations of 1-O-undecylglycerol for 48 hours. Cell index slopes were compared in each experiment.
Results: 1-O-undecylglycerol induced significant reduction of MCF-7 cell viability, and was less cytotoxic on 184B5 cells with 75µM. At 150µM was cytotoxic for both lines, but cell index slope of breast cancer cells was negative.
Conclusion: 1-O-undecilglicerol could be a candidate for future studies in in vivo models of breast cancer, and for further experiments about the mechanism involved in this effect.
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