Design and Evaluation of Matrix Diffusion Controlled Transdermal Patches of Diltiazem Hydrochloride

Authors

  • S. LAKSHMANA PRABU Dept. of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Madhav Nagar, Manipal – 576 104, Karnataka, India
  • AA SHIRWAIKAR Dept. of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Madhav Nagar, Manipal – 576 104, Karnataka, India
  • ANNIE SHIRWAIKAR Dept. of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Madhav Nagar, Manipal – 576 104, Karnataka, India
  • ARAVIND KUMAR Dept. of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Madhav Nagar, Manipal – 576 104, Karnataka, India
  • ABRAHAM JACOB Dept. of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Madhav Nagar, Manipal – 576 104, Karnataka, India

Keywords:

Diltiazem Hydrochloride, Eudragit RL PM, Polyvinyl pyrrolidone, Rosin, Release studies, Transdermal patch

Abstract

A matrix dispersion type transdermal drug delivery system of Diltiazem Hydrochloride was developed using differentratios of rosin with Eudragit RL PM and polyvinyl pyrrolidone. The patch prepared by the combination of rosin andpolyvinyl pyrrolidone was not transparent one, and shows an uneven distribution of polyvinyl pyrrolidone, which maybe due to the hydrophilic nature of polyvinyl pyrrolidone. The effect of the polymers on the technological properties,i.e., drug release, water vapor transmission rate, percentage moisture loss and thickness were investigated. The patchcontaining rosin: Eudragit RL PM (6:4) showed a release of 2651 mcg in 24 h. In order to improve the release variousproportions of camphor was included in the formulation. The patch containing rosin: Eudragit RL PM (6:4) with5% w/v of camphor showed a sustained release of the drug extending over a period of 24 h. Formulation F8 emergedas the most satisfactory formulation as far as the technological properties were concerned. Further skin permeationand skin irritation studies were carried out on rat skin and rabbit respectively. Therefore it can be concluded that thepatch containing rosin: Eudragit RL PM in the ratio 6:4 with 5%w/v of camphor achieved the desired objectives oftransdermal drug delivery systems, such as overcoming of fi rst pass effect, extended release and reduced frequency ofadministration.

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References

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Published

2008-09-20

How to Cite

1.
LAKSHMANA PRABU S, SHIRWAIKAR A, SHIRWAIKAR A, KUMAR A, JACOB A. Design and Evaluation of Matrix Diffusion Controlled Transdermal Patches of Diltiazem Hydrochloride. Ars Pharm [Internet]. 2008 Sep. 20 [cited 2025 Jun. 3];49(3):211-27. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4951

Issue

Vol. 49 No. 3 (2008)

Section

Original Articles

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