Assessment of anti-bacterial activity and brine shrimp toxicity of two Polygonum species

Authors

  • MA MAZID Phytopharmacology Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh
  • BK DATTA Department of Pharmaceutical Technology, University of Dhaka, Dhaka 1000, Bangladesh
  • L NAHAR School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Co. Londonderry, Northern Ireland, UK
  • SD SARKER School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Co. Londonderry, Northern Ireland, UK

Keywords:

Polygonum barbatum, Polygonum stagninum, Bangladeshi plants, Antibacterial, Brine shrimp lethality

Abstract

The extracts of the aerial parts of Polygonum barbatum var. barbata and Polygonum stagninum (Family: Polygonaceae)were assessed for anti-bacterial activity against a number of bacterial strains using the disc diffusion assay, andbrine shrimp toxicity using the brine shrimp lethality assay. All extracts/fractions, except the MeOH extract/fraction,exhibited low to moderate levels of anti-bacterial activity against most of the test strains (zone of inhibition = 7-21mm). All extracts and fractions displayed considerable general toxicity towards brine shrimps. The LD50 values of thetest extracts/fractions were within the range of 2.19 to 114.81 mg/mL, whereas that of the positive control (vincristinesulphate) was 0.61 mg/mL.

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References

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Published

2008-03-20

How to Cite

1.
MAZID M, DATTA B, NAHAR L, SARKER S. Assessment of anti-bacterial activity and brine shrimp toxicity of two Polygonum species. Ars Pharm [Internet]. 2008 Mar. 20 [cited 2025 Jun. 19];49(2):127-34. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4916

Issue

Vol. 49 No. 2 (2008)

Section

Original Articles

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