Determination of the stability of Kollicoat MAE 30D by means of differential scanning calorimetry

Authors

  • MªA RUIZ Departamento de Farmacia y Tecnología Farmacéutica. Facultad de Farmacia, Universidad de Granada, Campus de Cartuja, E-18071 Granada, Spain
  • M LÓPEZ-VIOTA Departamento de Farmacia y Tecnología Farmacéutica. Facultad de Farmacia, Universidad de Granada, Campus de Cartuja, E-18071 Granada, Spain
  • JL ARIAS Departamento de Farmacia y Tecnología Farmacéutica. Facultad de Farmacia, Universidad de Granada, Campus de Cartuja, E-18071 Granada, Spain
  • V GALLARDO Departamento de Farmacia y Tecnología Farmacéutica. Facultad de Farmacia, Universidad de Granada, Campus de Cartuja, E-18071 Granada, Spain

Keywords:

Nanomaterials, Biocompatible polymers, Kollicoat, DSC, SEM

Abstract

The stability of Kollicoat MAE 30 D was studied with differential scanning calorimetric, and scanning electronmicroscopy. We investigated the effects of pH, temperature and shaking on physicochemical properties of the latexparticles. Stability of the polymer as most strongly affected by pH; hence, we conclude that the stability of this latexreaches a maximum at acid pH values, where as stability is lost to pH 6.The particle shape and the mean diameter were determined by means of SEM microphotographs on 200 particles in asample of dry latex. The aqueous Kollicoat MAE 30 D dispersion, at its natural pH (2.5), presented one population ofparticles with a mean diameter of 1.56 nm.

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References

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Published

2008-03-20

How to Cite

1.
RUIZ M, LÓPEZ-VIOTA M, ARIAS J, GALLARDO V. Determination of the stability of Kollicoat MAE 30D by means of differential scanning calorimetry. Ars Pharm [Internet]. 2008 Mar. 20 [cited 2024 May 19];49(1):67-76. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4913

Issue

Vol. 49 No. 1 (2008)

Section

Original Articles

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