Effect of Enalapril on erythropoiesis recovery in murine anemia

Authors

  • TV VEUTHEY Laboratorio de Fisiología Humana, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur. San Juan 670 (8000) Bahía Blanca. Argentina.
  • MC D´ANNA Laboratorio de Fisiología Humana, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur. San Juan 670 (8000) Bahía Blanca. Argentina.
  • M SÁNCHEZ Laboratorio de Fisiología Humana, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur. San Juan 670 (8000) Bahía Blanca. Argentina.
  • CJ GATTI Laboratorio de Fisiología Humana, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur. San Juan 670 (8000) Bahía Blanca. Argentina.
  • ME ROQUE Laboratorio de Fisiología Humana, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur. San Juan 670 (8000) Bahía Blanca. Argentina.

Keywords:

ACE inhibitors, Anemia, Erythropoiesis, Kidney, Spleen

Abstract

The presence of Angiotensin receptors in erythropoietic bone marrow and marrow stromal cells clearly shows a mechanism forRennin-Angiotensin System-mediated regulation of erythropoiesis. The aim was to study the effects of Angiotensin-ConvertingEnzyme inhibition (ACEI) as Enalapril(E) on erythropoietic response in anemic mice treated with Phenylhydrazine (PHZ) bymeans of hematological and histological studies. Both PHZ and E-PHZ-treated mice showed hemolysis on day 14. Howeverthe restoration of anemic state occurred on day 16 in PHZ-treated mice and on day 20 in E-PHZ-treated mice. Erythropoieticactivity was observed in spleen (day16) and kidney (day20) of E-PHZ-treated mice. In PHZ-treated mice erythropoietic activitywas seen in spleen and kidney on day 16. We conclude that Inhibition of ACE with Enalapril delays the erythropoietic recoveryof hemolytic anemia in E-PHZ-treated mice. Erythropoietic activity in spleen and kidney suggest an involvement of theseorgans in the erythron recovery.

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Published

2008-03-20

How to Cite

1.
VEUTHEY T, D´ANNA M, SÁNCHEZ M, GATTI C, ROQUE M. Effect of Enalapril on erythropoiesis recovery in murine anemia. Ars Pharm [Internet]. 2008 Mar. 20 [cited 2024 May 19];49(1):51-66. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4912

Issue

Vol. 49 No. 1 (2008)

Section

Original Articles

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