Antibacterial and Cytotoxic Activities of Capparis zeylanica Linn Roots

Authors

  • M HAQUE Phytochemistry Research Laboratories, Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh
  • ME HAQUE Phytochemistry Research Laboratories, Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh
  • MM RAHMAN Phytochemistry Research Laboratories, Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh
  • P KHONDKAR Phytochemistry Research Laboratories, Department of Pharmacy, University of Rajshahi, Rajshahi-6205, Bangladesh
  • MM RAHMAN Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29–39 Brunswick Square, London WC1N 1AX, RU.

Keywords:

Capparis zeylanica, Capparidaceae, Antibacterial activity, Cytotoxicity

Abstract

Crude extracts and a fatty acid, octadec-7-en-5-ynoic acid (1), from the root bark of Capparis zeylanica Linn. (Fam.Capparidaceae) were screened for their antibacterial activities against Gram positive and Gram negative bacteria.Among the crude extracts, chloroform extract showed good activity against all test organisms. The fatty acid (1) isolatedfrom chloroform extract exhibited antibacterial activities against test organisms except E. coli. The activities werecompared to a standard antibiotic- kanamycin. The minimum inhibitory concentrations (MICs) of 1, determined byserial dilution technique, were found to be 64 μg/ml against Bacillus subtilis and Shigella dysenteriae. The cytotoxicactivities of crude extract and fatty acid (1) were observed by brine shrimp biassay and LC50 value of the compoundwas found to be 6.27 μg/ml

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Published

2008-03-20

How to Cite

1.
HAQUE M, HAQUE M, RAHMAN M, KHONDKAR P, RAHMAN M. Antibacterial and Cytotoxic Activities of Capparis zeylanica Linn Roots. Ars Pharm [Internet]. 2008 Mar. 20 [cited 2025 Apr. 2];49(1):31-7. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4910

Issue

Vol. 49 No. 1 (2008)

Section

Original Articles

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