Evaluation of the anti-wrinkle efficacy of cosmetic formulations with an anti-aging peptide (Argireline®)
Keywords:
Botox effect, Argireline®, Acetyl hexapeptide-8, Anti-Wrinkling EfficacyAbstract
The purpose of this research was to evaluate, by means of in vivo studies, the efficacy of new cosmetic active ingredients which effect of botox, called Argireline®), so that width and depth of wrinkles could be established. For this, it is prepared two formulations: an emulsion with an external aqueous phase for normal to dry skin, and a gel for oily skin. We likewise study the water content of the skin after the application of both formulas, as this must be one of the priority functions of facial treatments in general, as well as the level of satisfaction from the subjective point of view, fundamental for patients and their continuation of the treatment.After the designed tests, it is possible to verify that there is a remarkable diminution of the wrinkles size tested in each patient during the month of treatment. Besides, it is possible to review how the moisturizing capacity has been increased in all cases.At the end of the visual test, all the volunteers experienced a reduction in the depth of wrinkles, and from the subjective point of view, the appearance and elasticity of the skin were improved. Finally it is possible to conclude that Argireline® (acetyl hexapeptide-8 ) shows a great antiaging capacity in all the cases that have been studied and the tried compounds have increased moisturizing power.Downloads
References
E. López, Un nuevo activo antipolución y antienvejecimiento, NCP, 261, 12-17 (2002).
J. L. Parra and L. Pons, Ciencia Cosmética. Bases Fisiológicas y Criterios prácticos, (1995), pp. 170-181.
J.D. Carruthers and J.A. Carruthers, Treatment of glabellar frown lines with C. botulinum-A exotoxin, J. Dermatol. Surg. Oncol., 18, 17-21 (1992).
A. García and J. E. Fulton, Cosmetic denervation of de muscles of facial expression with botulinum toxin, Dermatol. Surg., 22, 39-43 (1996).
M. Fernández-Lorente, I. Aldanondo and P. Jaén, Efectos secundarios de la toxina botulínica, Piel, 20(9), 474-480 (2005).
G. C. Singh, M. C. Hankins, A. Dulku and M. B. Kelly, Psychosocial aspects of botox in aesthetic surgery, Aesthetic Plast. Surg., 30, 71-76 (2006).
M.A. Solá, Fotoenvejecimiento cutáneo. Clínica y tratamiento, El farmacéutico 272, 62-77 (2001).
M.A. Ruiz, B. Clares, M.E. Morales, S. Cazalla and V. Gallardo, Preparatyon and stability of cosmetic formulations with an anti-aging peptide, J Cosmet. Sci., 58, 157-171 (2007).
M. A. Ruiz , M. Pleguezuelos, M. Muñoz and V. Gallardo, Moisturizing capacity of aloe vera gel in skin creams made with silicone-based and olive oil-based latex preparations, J. of appl. Cosmet., 22, 25-33 (2004).
S. Siguri, A. Bonfigli, L. Rigano and R. Agostino, Lipstick and fragance sensory análisis, Cosmet. & Toilet., 114 (2), 37-43 (1999).
H. Stone, andJ.L Sidel, Sensory evaluation for skin care products, Cosmet. & Toilet., 101, 45-50 (1986).
L. Rigano and S. Siguri, Análisis Sensoriales: un instrumento para determinar la calidad en cosmética, NCP, 215, 5-9 (1996).
M. González and P. Palacio, Los cosméticos, ¿cuestionados por los sentidos?, Acófar, 448, 2 (2005).
M. Riera, Hidratación cutánea, NCP, 262, 5-9 (2002).
M. Rieger, Skin, water and moisturization, Cosmet. & Toilet., 104, 41 (1987).
A. Thibodeau, Inhibidores de Metaloproteinasas, NCP, 281, 5-10 (2005).
N.M. Craven, R.E.V. Watson, C.J.P. Jones, C.A. Schuttleworth, C.M. Kielly and C.E.M. Griffiths, Clinical features of photodamaged human skin are associated with a reduction in collagen VII, Br. J. Dermatol., 137, 344-350 (1997).
F.A. Fenske and C.W. Lober, Continuing and functional changes of normal aging skin, J Arner. Acad. Dermatol., 15(4), 571-585 (1986).
M.T.Alcalde, Productos cosméticos con efecto botox, OFFARM Farmacia y Sociedad, 23, 92-99 (2004).
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