Formulation and evaluation of sustained release microspheres of rosin containing aceclofenac

Authors

  • S Lakshmana Prabu Dept. of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Madhav Nagar, Manipal – 576 104, Karnataka, India
  • AA Shirwaikar Dept. of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Madhav Nagar, Manipal – 576 104, Karnataka, India
  • A Kumar Dept. of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Madhav Nagar, Manipal – 576 104, Karnataka, India
  • A Shirwaikar Dept. of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Madhav Nagar, Manipal – 576 104, Karnataka, India

Keywords:

Aceclofenac, Rosin, Microspheres, Sustained release

Abstract

Aceclofenac was microencapsulated using rosin by o/w emulsion solvent evaporationtechnique. The effect of three formulation variables including the drug:polymer ratio,emulsifier (polyvinyl alcohol) concentration and organic solvent (dichloromethane) volumewere examined. The prepared batches were characterized for microspheres particle sizedistribution, encapsulation efficiency and in vitro release behavior. The study reveals thatdrug:polymer ratio had a considerable effect on the entrapment efficiency, however particlesize distribution of microspheres was more dependent on the volume of dichloromethane andpolyvinyl alcohol concentration rather than on the drug: polymer ratio. Drug, polymerconcentrations were varied to obtain optimum release profile for sustaining the action of the drug

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Published

2009-06-20

How to Cite

1.
Lakshmana Prabu S, Shirwaikar A, Kumar A, Shirwaikar A. Formulation and evaluation of sustained release microspheres of rosin containing aceclofenac. Ars Pharm [Internet]. 2009 Jun. 20 [cited 2024 Jul. 22];50(2):51-62. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4885

Issue

Vol. 50 No. 2 (2009)

Section

Original Articles

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