Development of a Single Combined Microencapsulated Formulation of Allopurinol and Nimesulide and Investigation of Their Release Behaviours

Authors

  • SA Khan Faculty of Pharmacy & Alternative Medicine, the Islamia University of Bahawalpur, Bahawalpur, Pakistan.
  • M Ahmad Faculty of Pharmacy & Alternative Medicine, the Islamia University of Bahawalpur, Bahawalpur, Pakistan.
  • G Murtaza Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology Abbottabad, Pakistan.
  • MN Aamir Faculty of Pharmacy & Alternative Medicine, the Islamia University of Bahawalpur, Bahawalpur, Pakistan.
  • A Madni Faculty of Pharmacy & Alternative Medicine, the Islamia University of Bahawalpur, Bahawalpur, Pakistan.
  • R Kousar Faculty of Pharmacy & Alternative Medicine, the Islamia University of Bahawalpur, Bahawalpur, Pakistan.
  • U Minhas Faculty of Pharmacy & Alternative Medicine, the Islamia University of Bahawalpur, Bahawalpur, Pakistan.

Keywords:

Ibuprofen, Sustained release, Hydrophilic matrix, HPMC, Direct compression

Abstract

The aim of this study was to develop a single combined once-daily sustained releasemicroencapsulated dosage form of Allopurinol and Nimesulide using Ethyl cellulose as releasecontrolling factor and to evaluate drug release parameters as per various release kinetic models. Inorder to achieve required sustained release profile, microparticles were prepared using coacervationthermal change technique. The formulated microparticles were also characterized by physical andchemical parameters and results were found in acceptable limits. Different dissolution models wereapplied to drug release data in order to evaluate release mechanisms and kinetics. The drug releasedata fit well to the Higuchi expression. Drug release mechanism was found as a complex anomalousone.

Downloads

Download data is not yet available.

References

Yamuda T, Onishi H, Machida Y. Sustained release kitoprofen micropartieles with ethyl cellulose and carboxymethyl ethyl cellulose. J Control Release 2001; 75: 271-282.

Bakan JA, “Microencapsulation”, in The Theory and Practice of Industrial Pharmacy, Lachman L; Lieberman HA; Kanig JI; Ed. (Lea & Febiger, Philadelphia, PA, 2nd ed., 1986), pp. 412.

Ruiz TP, Lozano CM, Tomas V, Martin J. Determination of Allopurinol by micelle-stabilised room temperature phosphorescence in real samples. J Pharm Biomed Anal 2003; 32: 225–231.

Nuki G. Metabolic and genetic arthropathies. Medicine 2006; 34: 417–423.

Clarks M. Characterization and indentification of drugs. Ed. 12th, 1988.

Rabasseda X. Nimesulide: A selective cyclooxygenase-2 inhibitor anti-inflammatory drug. Drugs Today 1992; 32: 1-23.

Kulkarni SK. On the safety of Nimesulide, a preferential COX-2 inhibitor. Curr Sci 2002; 83: 1442-1443.

Famaey JP. In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by Nimesulide: An overview. Inflamm Res 1997; 46: 437–446.

Murtaza G, Ahamd M, Akhtar N, Rasool F. A comparative study of various microencapsulation techniques: effect of polymer viscosity on microcapsule characteristics. Pak J Pharm Sci 2009, 22: 291-300.

Parrott E. Milling. In: Lachman L, Liberman H, Kanig J. The theory and practice of industrial pharmacy. Philadelphia: Lea & Febiger. 1987.

Rowe RC, Sheskey RJ, Weller, PJ. Handbook of Pharmaceutical Excipients. Royal Publishers, London. 4th Ed. 2003.

Cox PJ, Khan KA, Munday DL, Sujja-areevath J. Development and evaluation of a multiple-unit oral sustained release dosage form for S(+)-ibuprofen: preparation and release kinetics. Int J Pharm 1999; 193: 73-84.

Downloads

Published

2010-06-20

How to Cite

1.
Khan S, Ahmad M, Murtaza G, Aamir M, Madni A, Kousar R, Minhas U. Development of a Single Combined Microencapsulated Formulation of Allopurinol and Nimesulide and Investigation of Their Release Behaviours. Ars Pharm [Internet]. 2010 Jun. 20 [cited 2024 Jul. 22];51(2):105-16. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4852

Issue

Vol. 51 No. 2 (2010)

Section

Original Articles

License

The articles, which are published in this journal, are subject to the following terms in relation to the rights of patrimonial or exploitation:

  1. The authors will keep their copyright and guarantee to the journal the right of first publication of their work, which will be distributed with a Creative Commons BY-NC-SA 4.0 license that allows third parties to reuse the work whenever its author, quote the original source and do not make commercial use of it.

b. The authors may adopt other non-exclusive licensing agreements for the distribution of the published version of the work (e.g., deposit it in an institutional telematic file or publish it in a monographic volume) provided that the original source of its publication is indicated.

c. Authors are allowed and advised to disseminate their work through the Internet (e.g. in institutional repositories or on their website) before and during the submission process, which can produce interesting exchanges and increase citations of the published work. (See The effect of open access).