Preparation, Characterization and In Vitro Evaluation of Aceclofenac Solid Dispersions

Authors

  • Dua Kamal Department of Pharmaceutical Technology, Faculty of Medicine & Health Sciences, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia-57000
  • Kavita Pabreja Vellore Institute of Technology, Vellore, Tamilnadu, India
  • MV Ramana Vellore Institute of Technology, Vellore, Tamilnadu, India

Keywords:

aceclofenac, urea, mannitol, PVP, PVP/VA-64

Abstract

The objective of the present investigation was to study the effect of various water soluble carriers likeurea, mannitol, PVP and PVP/VA-64 on in vitro dissolution of aceclofenac from solid dispersions.Aceclofenac binary solid dispersions (SD) with different drug loadings were prepared using themelting or fusion method. In vitro dissolution of pure drug, physical mixtures and solid dispersionswere carried out. Solid dispersion of aceclofenac with all four carriers (urea, mannitol, PVP andPVP/VA-64) showed considerable increase in the dissolution rate in comparison with physical mixtureand pure drug in 0.1 N HCl, pH1.2 and phosphate buffer, pH, 7.4. Solid dispersions containing PVPshowed maximum dissolution rate in comparison to formulation containing urea, mannitol andPVP/VA-64. Amorphous nature of the drug in solid dispersion was confirmed by scanning electronmicroscopy and a decrease in enthalpy of drug melting in solid dispersion compared to the pure drug.FT-IR spectroscopy and differential scanning calorimetry studies indicated no interaction betweenaceclofenac and carriers in solid dispersions in solid state. Dissolution enhancement was attributed todecreased crystallinity of the drug and to the wetting, eutectic formation and solubilizing effect of thecarrier from the solid dispersions of aceclofenac. In conclusion, dissolution of aceclofenac can beenhanced by the use of various hydrophilic carriers like urea, mannitol, PVP and PVP/VA-64.

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Published

2010-03-20

How to Cite

1.
Kamal D, Pabreja K, Ramana M. Preparation, Characterization and In Vitro Evaluation of Aceclofenac Solid Dispersions. Ars Pharm [Internet]. 2010 Mar. 20 [cited 2024 Jul. 22];51(1):57-76. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4846

Issue

Vol. 51 No. 1 (2010)

Section

Original Articles

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