Development and characterization of controlled release mucoadhesive tablets of captopril

Authors

  • HP Dalvadi C K Pithawalla Institute of Pharmaceutical Science and Research
  • JK Patel Nootan Pharmacy College
  • GC Rajput Nootan Pharmacy College
  • V Muruganantham Vinayaka Mission’s College of Pharmacy.
  • B Jayakar Vinayaka Mission’s College of Pharmacy.

Keywords:

Captopril, Gastro-retentive tablet, Mucoadhesive tablets, Swelling Index

Abstract

The present investigation concerns the development of mucoadhesive tablets of Captopril which were designed to prolong the gastric residence time after oral administration. Matrix tablets of Captopril were formulated using different mucoadhesive polymers such as guar gum, xanthan gum, hydroxyl propyl methyl cellulose K4M and K15M in various ratios. The tablets were evaluated for physical properties, content uniformity, swelling index, bioadhesive strength and in-vitro drug release. Swelling was increased as the concentration and viscosity of HPMC increases. Tablets formulated using guar gum and xanthan gum alone were eroded faster and dissolved completely within 5-7 hr, while tablet containing HPMC remain intact and provided slow release up to 11-12 hr. It was evident from the study that the formulation F10 containing HPMC K15M and xanthan gum (1:1) exhibited maximum bioadhesive strength of 31.59±0.05 gm and in vitro drug release was found to be 91.85 % at the end of 12 hr with non-fickian diffusion mechanism. The stability studies of optimized batch showed that there was no change in bioadhesive strength and in-vitro release when stored at different temperature condition for 60 days. It was concluded that formulation F10 shows the better bioadhesive strength and drug release.

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References

Deshpande AA, Rhodes CT, Shah NH, Malick AW. Controlledrelease drug delivery systems for prolonged gastric residence: an overview. Drug Dev Ind Pharm. 1996; 22 (6): 531-539.

Singh BN, Kim KH. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. J Control Rel. 2000; 63(3): 235–259.

Chavanpatil MD, Jain P, Chaudhari S, Shear R, Vavi PR. Novel sustained release, swellable and bioadhesive gastroretentive drug delivery system for ofloxacin. Int J Pharm. 2006; 316(1): 86–92.

Park, K. Robinson, J.R. Bioadhesive polymers as platforms for oral-controlled drug delivery: method to study bioadhesion. Int J Pharm. 1984; 19(2): 107–127.

Machida Y, Masuda H, Fujiyama N, Ito S, Iwata M, Nagai T. Preparation and phase II clinical examination of topical dosage form for treatment of carcinoma colli containing bleomycin with hydroxypropyl cellulose. Chem Pharm Bull. 1979; 27(1): 93–100.

Nagahara N, Akiyama Y, Nakao M, Tada M, Kitano MY. Mucoadhesive microspheres containing amoxicillin for clearance of Helicobacter pylori. Antimicrob Agents Chemother. 1998; 42(10): 2492–2494.

Singh B, Chakkal SK, Ahuja N. Formulation and Optimization of Controlled Release Mucoadhesive Tablets of Atenolol Using Response Surface Methodology. AAPS Pharm Sci Tech. 2006; 7 (1): E19-E28.

Mathiowitz E, Chickering DEI, Lehr CM. Bioadhesive Drug Delivery Systems. Marcel Dekker, New York. 1999.

Robinson JR, Mlynek GM. Bioadhesive and phase-change polymers for ocular drug-delivery. Adv Drug Deliver Rev. 1995; 16(1): 45–50.

Ziyaur Rahman M, Ali RK Khar. Design and evaluation of bilayer floating tablets of captopril. Acta Pharm. 2006; 56:49–57.

Anaizi NH, Swenson C. Instability of captopril solution. Am J Hosp Pharm. 1993; 50: 486–488.

Seta Y, Kawahara Y, Nishimura K, Okada R. Design and preparation of captopril sustained release dosage forms and their biopharmaceutical properties. Int J Pharm. 1988; 41(3): 245–254.

Nafee NA, Ismail FA, Nabila AB, Mortada LM. Mucoadhesive Delivery Systems. II. Formulation and In-Vitro/In-Vivo Evaluation of Buccal Mucoadhesive Tablets Containing Water-Soluble Drugs. Drug Dev Ind Pharm. 2004; 30 (9): 995–1004.

Chowdary KPR. Suresh B, Sangeeta B, Reddy GK. Design and Evaluation of Diltiazem Mucoadhesive Tablets for Oral Controlled Release. Saudi Pharm J. 2003; 11(4): 201-205.

Lachman L, Lieberman HA, Kanig JL. The theory and practice of industrial pharmacy. 3rd Ed. Varghese publishing house: Mumbai, 1987; 293-345.

Baumgartner S, Kristel J, Vreer F, Vodopivec P, Zorko B. Optimization of floating matrix tablets and evaluation of their gastric residence time. Int J Pharm. 2000; 195(1-2): 125-135.

Singh B, Ahuja N. Development of controlled-release buccoadhesive hydrophilic matrices of diltiazem hydrochloride: optimization of bioadhesion, dissolution, and diffusion parameters. Drug Dev Ind Pharm. 2002; 28(4): 431-442.

Duchene D, Touchard F, Peppas N. Pharmaceutical and medical aspects of bioadhesive systems for drug administration. Drug Dev Ind Pharm. 1988; 14(2): 283–318.

Lueßen HL, Lehr CM, Rentel CO, Noach AB, de Boer JAG, Verhoef JC, Junginger HE. Bioadhesive polymers for the peroral delivery of peptide drugs. J Control Rel. 1994; 29: 329–338.

Wang, J.,Tabata,Y., Bi, D., Morimoto, K., Evaluation of gastric mucoadhesive properties of aminated gelatin microspheres. J. Control. Rel. 2001; 73: 223–231.

Xu G, Sunada H. Influence of formulation change on drug release kinetics from HPMC matrix tablet. Chem Pharm Bull. 1995; 43(3): 538-550.

Bamba M, Puisieusx F. Release mechanism in gel forming sustained release preparations. Int J Pharm. 1979;2(5-6):307-315

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Published

2011-06-20

How to Cite

1.
Dalvadi H, Patel J, Rajput G, Muruganantham V, Jayakar B. Development and characterization of controlled release mucoadhesive tablets of captopril. Ars Pharm [Internet]. 2011 Jun. 20 [cited 2024 Jul. 22];52(2):31-7. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4722

Issue

Vol. 52 No. 2 (2011)

Section

Original Articles

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