In-vitro studies of diclofenac sodium controlled-release dosage from biopolymeric hydrophilic matrices

Authors

  • TNK Suriyaprakash Dept of Pharmaceutics, Periyar College of Pharm. Sciences
  • SL Prabu Dept. of Pharm. Technology, Anna University of Technology
  • T Satyam Dept of Pharmaceutics, Periyar College of Pharm. Sciences

Keywords:

Diclofenac sodium, HPMC, Eudragit NE 30D, Sustained release matrix, Tablet disintegrant

Abstract

The objective of the present study was to develop diclofenac sodium tablets from polymeric matrices [HPMC K-15 and Eudragit NE 30D] and characterization of its physicochemical properties, invitro release studies by using different disintegrants like sodium starch glycollate and polyplasdone in different ratios to optimize its release profile with the standard market product. Matrix tablets were prepared by wet granulation method using PVP K30 as binding agent. The method of preparation of matrix system and its concentration were found to have pronounced effect on the release of diclofenac sodium The matrix tablets were evaluated for its thickness, hardness, friability, weight variation, drug content and invitro release studies. The drug delivery was analyzed using the paddle method according to USP XXIII, all the studies were done in phosphate buffer pH 6.8. The dissolution release profile of formulation made with Eudragit NE 30 D (10%w/w) with polyplasdone (2%w/w) was comparable with the market formulation and the f1 and f2 value were found to be 6.28 and 67.17. Stability studies were carried out as per ICH guidelines and tested for its physicochemical properties and invitro studies. The stability study results revealed that the prepared formulation was stable in the stress condition.

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Published

2011-06-20

How to Cite

1.
Suriyaprakash T, Prabu S, Satyam T. In-vitro studies of diclofenac sodium controlled-release dosage from biopolymeric hydrophilic matrices. Ars Pharm [Internet]. 2011 Jun. 20 [cited 2024 Dec. 22];52(2):20-4. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4720

Issue

Vol. 52 No. 2 (2011)

Section

Original Articles

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