RP-HPLC method for simultaneous estimation of atorvastatin calcium and ramipril from plasma.

Authors

  • VH Potdar Department of Pharmacology. Tatyasaheb Kore College of Pharmacy, Warananagar
  • VS Mule Department of Pharmacology. Tatyasaheb Kore College of Pharmacy, Warananagar
  • SA Pishawikar Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Morewadi
  • SD Jadhav Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Morewadi
  • SL Thamake Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy, Morewadi

Keywords:

Solid lipid microparticles, ketoprofen, solvent evaporation method

Abstract

Solid lipid microparticles (SLMs) loaded with ketoprofen were prepared by single emulsion-solvent evaporation method, in which glyceryl monostearate and Tween 80 were employed. The particle size was found to be 99.80±2.1μm. Microparticles observed by scanning electron microscope (SEM) showed spherical shape. The entrapment efficiency (EE %) and drug loading capacity (DL %) were found to be 72.60±1.6 % and 17.98±0.7% respectively. Results of stability evaluation showed relatively long term stability after storage at 4˚C for 3 months. The in-vivo study revealed slightly better per cent inhibition of pain i.e. 74% in comparison with 68% produced by plain drug.

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Published

2011-06-20

How to Cite

1.
Potdar V, Mule V, Pishawikar S, Jadhav S, Thamake S. RP-HPLC method for simultaneous estimation of atorvastatin calcium and ramipril from plasma. Ars Pharm [Internet]. 2011 Jun. 20 [cited 2024 Jul. 22];52(2):14-9. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4719

Issue

Vol. 52 No. 2 (2011)

Section

Original Articles

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