Formulation and in vitro characterization of metoprolol tartrate loaded chitosan microspheres

Authors

  • Bharti D. Adi School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishawavidyalaya, Bhopal, India-462036
  • Keservani K. Raj School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishawavidyalaya, Bhopal, India-462036
  • Sharma K. Anil School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishawavidyalaya, Bhopal, India-462036
  • Kesharwani K. Rajesh Division of Applied Science and Indo-Russian Center for Biotechnology [IRCB], Indian Institute of Information Technology, Allahabad, India-211012
  • Husain M. Gulam Department of Pharmaceutics, Banaras Hindu University, Varanasi, India- 221005

Keywords:

Metoprolol tartrate, Chitosan Microspheres, Microphotograph

Abstract

Aim: The main objective of present study was to facilitate intranasal delivery of Metoprolol tartrate (cardioselective β1-blocker) by formulating mucoadhesive microspheres.

Methods: The microspheres were prepared by ionic precipitation and chemical cross-linking method. Microsphere formulations were characterized for particle size, surface morphology, entrapment efficiency, in vitro drug release and Infrared Spectroscopy.

Results: The particle size and maximum entrapment of optimized formulation (MT 4) was found to be 1897 nm, 94.19±0.015 %, respectively. In vitro drug release in phosphate buffer saline (pH 7.4) was maximum (97.88±0.02 %) in formulation MF1. The drug release rate can be tailored by manipulating the degree of crystallinity, reduced crystallinity is favorable when slow release is desired. The drug employed can induce polymer chain scission through nucleophilic degradation. The results of the infrared analysis were in agreement with reference as no new chemical species after the microencapsulation process was observed.

Conclusions: To conclude, the drug (metoprolol tartrate) thus released in nasal mucosa will attain therapeutic plasma concentration and reduce elevated blood pressure levels.

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Published

2012-09-20

How to Cite

1.
Adi BD, Raj KK, Anil SK, Rajesh KK, Gulam HM. Formulation and in vitro characterization of metoprolol tartrate loaded chitosan microspheres. Ars Pharm [Internet]. 2012 Sep. 20 [cited 2024 Aug. 24];53(3):13-8. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4680

Issue

Vol. 53 No. 3 (2012)

Section

Original Articles

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