Preparation and characterization of an oily suspension for administration of omeprazole in children

Authors

  • C Cano Corral Servicio de Farmacia, Hospital SAS Jerez de la Frontera, Jerez de la Frontera, Cádiz (España)
  • ML González Rodríguez Departmento de Farmacia y Tecnología Farmacéutica, Universidad de Sevilla, (España)
  • JI Pérez Martínez Departmento de Farmacia y Tecnología Farmacéutica, Universidad de Sevilla, (España)
  • C Alarcón-Payer Servicio de Farmacia, Hospital Universitario Virgen de las Nieves, Granada (España)
  • I Martínez López Servicio de Farmacia, Hospital SAS Jerez de la Frontera, Jerez de la Frontera, Cádiz (España)
  • A Rabasco Álvarez Departmento de Farmacia y Tecnología Farmacéutica, Universidad de Sevilla, (España)

Keywords:

Omeprazole, Oily Suspension, Pediatric formula

Abstract

Aim: Develop an oral omeprazole suspension for use in the pediatric population.

Methods: For the development of the formulation was used active ingredient in powder instead of pellets, which is usually used. By instability of the drug in acid medium, we developed a preparation of an oily character. Studies were conducted to characterize the oil vehicle, organoleptic characteristics, sedimentation volume and used the technique of differential scanning calorimetry (DSC) for studies of viscosity and drug-excipient compatibility.

Results: The percentages in which the emulsified non formula were 1,54% and 4,1% surfactant agent. In the thermogram was observed that the peak melting temperature and enthalpy values of omeprazole were diminished by the presence of aspartame and also a change in the melting peak equal to 10ºC, indicating a possible interaction between omeprazole and aspartame.

Conclusions: As far as the study did managed to stabilize all components of the formula, except the sweetener should be replaced by another similar power to reach the desired formula.

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Published

2012-06-20

How to Cite

1.
Cano Corral C, González Rodríguez M, Pérez Martínez J, Alarcón-Payer C, Martínez López I, Rabasco Álvarez A. Preparation and characterization of an oily suspension for administration of omeprazole in children. Ars Pharm [Internet]. 2012 Jun. 20 [cited 2024 Jul. 17];53(2):29-35. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4668

Issue

Vol. 53 No. 2 (2012)

Section

Original Articles

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