Improvement of flowability, compressibility and dissolution of aceclofenac by emulsion solvent diffusion with polyethylene glycol.

Authors

  • SV Patil 1.Department of Pharmaceutics, University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Orissa. India. 2. Department of Pharmaceutics, Ashokarao Mane College of Pharmacy, Peth-Vadgaon, Maharashtra, India.
  • N Pati Department of Pharmaceutics, University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Orissa. India.
  • SK Sahoo Department of Pharmaceutics, University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Orissa. India.

Keywords:

Spherical crystallization, Compressibility, Polyethylene glycol

Abstract

Aim: The objective behind this study is to improve the compressibility, flowability, packability and dissolution rate of aceclofenac by preparing spherical crystals using quasi emulsion solvent diffusion method.

Materials and Method: Spherical agglomerates of aceclofenac were effectively prepared using acetone, dichloromethane and 0.1 N HCl as good solvent, bridging liquid and poor solvent respectively with different concentrations of polyethylene glycol 6000 in poor solvent.

Results: Prepared agglomerates were spherical with enhanced fragmentation and less elastic recovery. Particle size, flowability, compactibility, packability, solubility and dissolution rate of agglomerates were preferably improved for direct compression compared with raw crystal of aceclofenac. X-ray powder diffraction and differential scanning calorimetry study indicated slight amorphization of drug during recrystallization but not associated with any chemical transition indicated by Fourier transforms infrared spectra.

Conclusion: The present research improved tableting properties and dissolution characteristics of aceclofenac.

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Published

2012-06-20

How to Cite

1.
Patil S, Pati N, Sahoo S. Improvement of flowability, compressibility and dissolution of aceclofenac by emulsion solvent diffusion with polyethylene glycol. Ars Pharm [Internet]. 2012 Jun. 20 [cited 2024 Aug. 24];53(2):21-7. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4667

Issue

Vol. 53 No. 2 (2012)

Section

Original Articles

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