Analysis of bucoadhesive systems

Authors

  • Herminia Castán Urbano Departamento de Farmacia y Tecnología Farmacéutica. Universidad de Granada. España
  • María Encarnación Morales Hernández Departamento de Farmacia y Tecnología Farmacéutica. Universidad de Granada. España
  • Beatriz Clares Naveros Departamento de Farmacia y Tecnología Farmacéutica. Universidad de Granada. España
  • Ana Cristina Calpena Campmany Departamento de Farmacia y Tecnología Farmacéutica. Universidad de Barcelona. España.
  • María Adolfina Ruíz Martínez Departamento de Farmacia y Tecnología Farmacéutica. Universidad de Granada. España

Keywords:

Bucoadhesive patch, doxepin hydrochloride, administration transbuccal, calorimetric analysis, swelling

Abstract

Aim: The aim of this study is to design a bucoadhesive patch for the transbuccal administration of doxepin hydrochloride using different polymers as well as the characterization of these systems for calorimetric analysis and the swelling capacity.

Materials and methods: Doxepin hydrochloride was used as well as various polymers; carboxymethylcellulose sodium, hydroxypropylmethyl cellulose and chitosan. Differential scanning calorimetry (DSC) was carried out using a Mettler FP 80 device equipped with a FP 85 oven and the swelling capacity using agar plates.

Results: Thermograms obtained patches and physical mixtures where there are endothermic transitions between 30 and 120º C and the endothermic peak of the active principle in binary physical mixtures. Dehydration enthalpy is similar in polymers of carboxymethylcellulose sodium and chitosan (281 J/g), the film having less hydroxypropylmethylcellulose (251 J/g), the percentage of moisture shows that the patches prepared with hydroxypropylmethylcellulose have less tendency to collect water (55.91 %) compared to 67.04 % and 67.30 % with sodium carboxymethylcellulose and chitosan, respectively.

Conclusion: The results show that there is compatibility between the components of the formulation and the enthalpy data correlate with the data obtained in the swelling test.

Downloads

Download data is not yet available.

References

Tura B, Tura SM. The analgesic effect of tricyclic 1. antidepressant. Brain Res. 1990; 518: 19-22.

Peter C, Watson N. Antidepressant drugs as adjuvant 2. analgesics. J Pain and Symptom Manag. 1994; 9(6): 392-405.

Korzeniewska-Rybicka I, Plaznik A. Analgesic effect of 3. antidepressant drugs. Pharmacol Biochem Behav. 1998; 59(2): 331-338.

Onghena P, Van Houdenhove B. The antidepressant-4. induced analgesic effects. Bailliere Clin Anaes. 1998; 12(1): 53-68.

Sudoh Y, Cahoon EE, Gerner P. Tricyclic antidepressant as 5. long acting local anesthetics. Pain. 2003; 103: 49-55.

Micó JA, Ardid D, Berrocoso E, Eschalier A. Antidepressants 6. and pain. Trends Pharmacol Sci. 2006; 27(7): 348-354.

McCleane G. Analgésicos por vía tópica. Anesthesiol Clin 7. N A. 2007; 25: 825-839.

Birudaraj R, Mahalingam R, Li X, Jasti BR. Advances in 8. buccal drug delivery. Crit Rev Ther Drug. 2005; 22(3): 295-330.

Smart JD. Buccal drug delivery. Expert Opin Drug Del. 9. 2005; 2(3): 507-517.

Maurya SK, Pathak K, Bali V. Therapeutic potential of 10. mucoadhesive drug delivery systems--an updated patent review. Recent Pat Drug Deliv Formul. 2010; 4(3): 256-265.

Patel VF, Liu F, Brown MB. Advances in oral transmucosal 11. drug delivery. J Control Release. 2011; 153(2): 106-116.

Nafee NA, Ismail FA, Boraie NA, Mortada LM. 12. Mucoadhesive buccal patches of miconazole nitrate: in vitro/in vivo performance and effect of ageing. Int J Pharm. 2003; 264: 1-14.

Perioli L, Ambrogi V, Angelici F et al. Development 13. of mucoadhesive patches for buccal administration of ibuprofen. J Control Release. 2004; 99: 73-82.

Don TM, Huang ML, Chiu AC, Kuo KH, Chiu WY, Chiu 14. LH. Preparation of thermo-responsive acrylic hydrogels useful for the application in transdermal drug delivery systems. Mater Chem Phys. 2008; 107: 266-273.

Derle D, Joshi O, Pawar A, Patel J, Perdeshi V. Effect 15. of tablet excipients on mucoadhesive properties of polyoxyethylene and carbopol 971 P. Int J Pharm Pharm Sci. 2009; 1(1): 198-205.

Downloads

Published

2013-06-20

How to Cite

1.
Castán Urbano H, Morales Hernández ME, Clares Naveros B, Calpena Campmany AC, Ruíz Martínez MA. Analysis of bucoadhesive systems. Ars Pharm [Internet]. 2013 Jun. 20 [cited 2024 Jul. 22];54(2):39-43. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4638

Issue

Vol. 54 No. 2 (2013)

Section

Original Articles

License

The articles, which are published in this journal, are subject to the following terms in relation to the rights of patrimonial or exploitation:

  1. The authors will keep their copyright and guarantee to the journal the right of first publication of their work, which will be distributed with a Creative Commons BY-NC-SA 4.0 license that allows third parties to reuse the work whenever its author, quote the original source and do not make commercial use of it.

b. The authors may adopt other non-exclusive licensing agreements for the distribution of the published version of the work (e.g., deposit it in an institutional telematic file or publish it in a monographic volume) provided that the original source of its publication is indicated.

c. Authors are allowed and advised to disseminate their work through the Internet (e.g. in institutional repositories or on their website) before and during the submission process, which can produce interesting exchanges and increase citations of the published work. (See The effect of open access).