Colorimetric method for simultaneous estimation of amlodipine besylate from plasma.

Authors

  • Rajendra C. Doijad Shree Santkrupa College of Pharmacy, Ghogaon, Karad Maharashtra 415111 (India);
  • Poournima S. Sankpal Shree Santkrupa College of Pharmacy, Ghogaon, Karad Maharashtra 415111 (India);
  • Harinath N. More Bharati Vidyapeeth’s College of Pharmacy, Kolhapur Maharashtra 415111 (India)
  • Sachin A. Pishwikar Bharati Vidyapeeth’s College of Pharmacy, Kolhapur Maharashtra 415111 (India)
  • Asma B. Pathan Shree Santkrupa College of Pharmacy, Ghogaon, Karad Maharashtra 415111 (India);
  • Gayathri B. Suryawanshi Shree Santkrupa College of Pharmacy, Ghogaon, Karad Maharashtra 415111 (India);

Keywords:

Amlodipine besylate, colorimetric method.

Abstract

Aim: The present work was to develop the method of analysis which can estimate drug in combined form without prior separation.

Materials and method: By using UV spectroscopy colorimetric method was used for determination of Amlodipine besylate (AML) from plasma.

Result and conclusion: This method is based on the formation of green colour in reaction between AML and 0.4 % Ferric chloride (FC) and 0.2 % Potassium ferricyanide (PF).The absorbance was measured at 775 nm. Result of tablet analysis showed % S.D. values in the range of 098.22 to 100,63%. Standard deviation value for tablet analysis by using methanol ranging from 98.01 to 101,13 % which proves the ability of the method to remain unaffected by small but deliberate change in reaction conditions and this method is used for estimation of AML from biological samples.

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References

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Published

2013-03-20

How to Cite

1.
Doijad RC, Sankpal PS, More HN, Pishwikar SA, Pathan AB, Suryawanshi GB. Colorimetric method for simultaneous estimation of amlodipine besylate from plasma. Ars Pharm [Internet]. 2013 Mar. 20 [cited 2024 Jul. 22];54(1):1-6. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4575

Issue

Vol. 54 No. 1 (2013)

Section

Original Articles

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