Activity of albendazole and essential oils of peppermint (Mentha piperita) and chamomile (Matricaria chamomilla) against Anisakis type I

Authors

  • María del Carmen Romero López Departamento de Parasitología. Facultad de Farmacia. Universidad de Granada. (España)
  • María Concepción Navarro Moll Departamento de Farmacología. Facultad de Farmacia. Universidad de Granada. (España)
  • Joaquina Martín Sánchez Departamento de Farmacología. Facultad de Farmacia. Universidad de Granada. (España)
  • Adela Valero López Departamento de Parasitología. Facultad de Farmacia. Universidad de Granada. (España)

Keywords:

Anisakis, Albendazole, Chamomile, Mentha, PCR-RFLP

Abstract

Aim: We have studied the possible synergistic activity of the essential oils of Mentha piperita and Matricaria chamomile against Anisakis type I.

Materials and methods: the larvicidal activity of the mixture of essential oils was tested in vitro and in vivo, using as a reference the drug Albendazole and effectiveness measured through a statistical model.

Results: The in vitro and in vivo experiments both evidenced that the larvicidal activity of essential oils, was higher than the Albendazole activity. In the in vitro assay, at concentrations of 250 and 187.5 μg/ml, the mortality was 100% with the mixture of essential oils while albendazole was ineffective at the concentrations studied. In the in vivo assay, the mixture of essential oils, was significantly more effective in the reduction of numbers of lesions with rats in comparison to albendazole treatments and control. Albendazole did not significantly reduce the percentage of lesions caused by larvae vs. control.

Conclusion: Considering the results, we have come to the conclusion that the mixture of peppermint essential oils and chamomile could be used in the treatment/prophylaxis of human Anisakis.

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References

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Published

2014-03-20

How to Cite

1.
Romero López M del C, Navarro Moll MC, Martín Sánchez J, Valero López A. Activity of albendazole and essential oils of peppermint (Mentha piperita) and chamomile (Matricaria chamomilla) against Anisakis type I. Ars Pharm [Internet]. 2014 Mar. 20 [cited 2024 Dec. 22];55(1):45-9. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4378

Issue

Vol. 55 No. 1 (2014)

Section

Short Articles

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