Design and evaluation of cedrela gum based microparticles of theophilline.

Authors

  • Michael Ayodele Odeniyi Dept. of Pharmaceutics & Industrial Pharmacy, University of Ibadan, Ibadan, Nigeria.
  • Hirofumi Takeuchi Dept of Pharmaceutical Engineering, Gifu Pharmaceutical University, Gifu, Japan.

Keywords:

Cedrela gum, Drug release, Microparticles, Spray drying, Theophylline

Abstract

Aim: The purpose of this study was to develop microparticles of theophylline employing Cedrela gum, a novel natural gums, as a polymer by spray drying method.

Materials and Methods: The process parameters were different spray drying temperatures of 110º, 130º and 150ºC. The microparticles were evaluated for characteristics like particle size, incorporation efficiency, thermal analysis, X-ray diffraction (XRD) analysis and in vitro drug release.

Results: The microparticles were spherical with distorted surface morphology. The particle size ranged from 35.6 to 58.0 μm depending on the spray drying temperature. Differential scanning calorimetry (DSC) studies revealed that theophiline was molecularly dispersed at all operating temperatures. The release of drug from the microparticles was immediate with no lag time with complete release obtained from the microparticles prepared at the highest temperature.

Conclusion: Cedrela gum could serve as a carrier for solid dispersion of drugs such as Theophilline by means of spray drying at a temperature as low as 110ºC. Microspheres obtained at this temperature were smaller, more free flowing and less susceptible to agglomeration.

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Published

2014-03-20

How to Cite

1.
Ayodele Odeniyi M, Takeuchi H. Design and evaluation of cedrela gum based microparticles of theophilline. Ars Pharm [Internet]. 2014 Mar. 20 [cited 2024 Jul. 22];55(1):30-6. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/4374

Issue

Vol. 55 No. 1 (2014)

Section

Original Articles

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