Formulation of mucoadhesive microspheres of rosiglitazone maleate and its in vitro evaluation using ionotropic gelation technique
Keywords:
mucoadhesive microspheres, rosiglitazone maleate, sustained release.Abstract
Aim: The objective of the present study is to design and evaluate mucoadhesive microspheres for oralcontrolled release.
Materials and Method: Rosiglitazone maleate microspheres with a coat consisting of alginate and a mucoadhesivepolymer sodium carboxymethylcellulose, carbopol 934P and hydroxypropylmethylcellulosewere prepared by an orifice-ionic gelation process. The microspheres were evaluated for FTIR studies,morphology, particle size, micromeritic properties, percentage entrapment efficiency, in-vitro wash-offtest and in-vitro release studies.
Results: The resulting microspheres were spherical and free flowing. The percent entrapment efficiencywas 68.2 to 85.6%. The microspheres exhibited good mucoadhesive property in the in vitro wash-off test.Rosiglitazone release from these mucoadhesive microspheres was slow and extended over 12 h durationof time depending on the composition of coat.
Conclusions: The prepared mucoadhesive microspheres are thus suitable for oral controlled release ofRosiglitazone maleate and thereby help in the management of type II diabetes mellitus.
Downloads
References
Tenpe CR, Yeole PG. Comparative evaluation of antidiabetic activity of some marketed polyherbal formulations in alloxan induced diabetic rats. Int J Pharm Tech Res. 2009; 1(1): 43-49
Silva CM, Ribeiro AJ, Ferreira D, Veiga F. Insulin encapsulation in reinforced alginate microspheres prepared by internal gelation. Eur J Pharm Sci. 2006; 29: 148-159
Lin WC, Yu DG, Yang MC. pH-sensitive polyelectrolyte complex gel microspheres composed of chitosan/sodium tripolyphosphate/dextran sulfate: swelling kinetics and drug delivery properties. Colloids and surfaces B: Biointerfaces. 2005; 44: 143-151
Adikwu MU, Yoshikawa Y, Takada K. Bioadhesive delivery of Metformin using prosopsis gum with antidiabetic potential. Bio Pharm Bull. 2003; 26(5): 662-666
Sachan NK and Bhattacharya A (2009) Modeling and characterization of drug release from glutinous rice starch based Hydrogel beads for controlled drug delivery. Int J Health Res. 2(1): 93-99
Bonacucina G, Martelli S, Palmieri GF. Rheological, mucoadhesive and release properties of carbopol gels in hydrophilic cosolvents. Int J Pharm. 2004; 282: 115-130
Chun MK, Cho CS, Choi HK. Mucoadhesive microspheres prepared by interpolymer complexation and solvent diffusion method. Int J Pharm. 2005; 288: 295-303
Kamila MM, Mondal N, Ghosh LK, Gupta BK. Multiunit floating drug delivery system of Rosiglitazone maleate: Development, characterization, statistical optimization of drug release and in vivo evaluation AAPS PharmSciTech. 2009; 10(3): 887-99.
Garud N, Garud A, Jain N. Formulation design and in-vitro evaluation of metformin microspheres using ionotropic gelation technique. Journal of Pharmacy Research. 2011; 4(7): 2103-2106
Lachman L, Lieberman HA, Kanig JL. The theory and practice of industrial pharmacy, 4th Edition, Varghese Publishing House, Dadar, Bombay. 1991; 183-184
Badhana S, Garud N, Garud A. Colon Specific Drug Delivery of Mesalamine using Eudragit S100-coated chitosan microspheres for the treatment of ulcerative colitis. International Current Pharmaceutical Journal 2013; 2(3): 42-48
Chaudhary A, Garud N, Garud A. Formulation and in-vitro characterization of floating drug delivery system of Nateglinide. Am J PharmTech Res. 2013; 3(2): 477-486
Garud N and Garud A. Preparation and In-vitro Evaluation of Metformin Microspheres using Non-aqueous Solvent Evaporation Technique, Trop J Pharm Res. 2012; 11(4): 577-583.
Chowdary KPR, Rao YS. Mucoadhesive microcapsules of glipizide: characterization, in vitro and in vivo evaluation. Indian J Pharm Sci, 2003; 65(3): 279-284
Nayak BS, Ghosh SK, Patro KTB. Preparation and characterization of famotidine microcapsule employing Mucoadhesive polymers in combination to enhance gastroretention for oral delivery. IJPPS. 2009; 1(2): 112-120
Swapna A, Mohd AB, Wamorkar V, Swathimutyam P. Formulation and Evaluation of Mesalamine Microspheres for Colon Targeted Drug Delivery System. Journal of Pharmacy Research. 2011; 4(6): 1670-1672.
Ch’ng HS, Park H, Kelly P, Robinson JR. For oral controlled delivery, II: synthesis and evaluation of some swelling, water-insoluble bioadhesive polymers. J Pharm Sci. 1985; 74: 399-405
El Hameed MDA, Kellaway IW. Preparation and in vitro characterization of mucoadhesive polymeric microspheres as intra-nasal delivery systems. Eur J Pharm Biopharm. 1977; 44: 53-60
Gangadharappa HV, Biswas S, Getyala A, Gupta VN, Pramod Kumar TM. Development, in vitro and in vivo evaluation of novel floating hollow microspheres of rosiglitazone maleate. Der Pharmacia Lettre. 2011; 3(4): 299-316
Downloads
Published
How to Cite
Issue
Section
License
The articles, which are published in this journal, are subject to the following terms in relation to the rights of patrimonial or exploitation:
- The authors will keep their copyright and guarantee to the journal the right of first publication of their work, which will be distributed with a Creative Commons BY-NC-SA 4.0 license that allows third parties to reuse the work whenever its author, quote the original source and do not make commercial use of it.
b. The authors may adopt other non-exclusive licensing agreements for the distribution of the published version of the work (e.g., deposit it in an institutional telematic file or publish it in a monographic volume) provided that the original source of its publication is indicated.
c. Authors are allowed and advised to disseminate their work through the Internet (e.g. in institutional repositories or on their website) before and during the submission process, which can produce interesting exchanges and increase citations of the published work. (See The effect of open access).
