Protein and Peptide in Drug Targeting and its Therapeutic Approach

Raj K. Keservani; Anil K. Sharma; Urmila Jarouliya

doi:10.4321/s2340-98942015000300006

Autores/as

Raj K. Keservani School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal
Anil K. Sharma Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, New Delhi
Urmila Jarouliya School of Studies in Biotechnology, Jiwaji University, Gwalior (M.P)

DOI:

https://doi.org/10.4321/s2340-98942015000300006

Palabras clave:

proteína, péptido, liberación controlada, polímero bioerosionable

Resumen

Objetivo. El objetivo principal de este artículo de revisión es proporcionar información sobre las ventajas de las proteínas y péptidos a través de diferentes vías de administración de fármacos, dirigidos a un sitio en particular y su implicación en el sistema de administración de fármacos.

Métodos. Con ese objetivo, los sitios web de PubMed, HCAplus, Thomson, se utilizaron como las principales fuentes para realizar la búsqueda de los artículos de investigación más importantes publicados sobre el tema. La información fue luego cuidadosamente analizada, destacando los resultados más importantes en el desarrollo de proteína y péptido de direccionamiento de drogas, así como su actividad terapéutica.

Resultados. En los últimos años muchos investigadores utilizan las proteínas y los péptidos como un sitio diana de fármaco por un sistema de administración diferente. Las proteínas y los péptidos se utilizan como agentes terapéuticos específicos y eficaces, debido a la inestabilidad y los efectos secundarios de su uso es complicado. Las proteínas quinasas son reguladores importantes de la mayoría, si no todos, los procesos biológicos. La actividad anormal de proteínas y péptidos se ha implicado en muchas enfermedades humanas, tales como diabetes, cáncer y trastornos neurodegenerativos.

Conclusión. Finalmente concluyó que la proteína y el péptido se utilizaron en fármaco que se dirige al sitio específico y también se utiliza en diferentes estados de enfermedad como el cáncer, la diabetes, como sustancias inmunomoduladora, efectos neurodegenerativos y actividad antimicrobiana.

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