Assessment of the Risk of Atherogenicity and Cardiometabolic Health in Type II Diabetes Mellitus
DOI:
https://doi.org/10.30827/ars.v66i4.32268Keywords:
Diabetes; Atherogenic index; Lipid prophile; blood sugarAbstract
Introduction: Diabetes mellitus is a metabolic disorder characterized by persistently high blood sugar levels and variable levels of impairment in the metabolism of proteins, lipids, and carbohydrates. There is a one to fivefold increase in sudden mortality, and there is a high risk of numerous diseases, including cardiovascular disease, it encompasses coronary artery disease, myocardial infarction, congestive heart failure, and peripheral vascular disease. A new measure for assessing atherogenicity risk and cardiometabolic health is the atherogenic index of plasma, which is the logarithmically transformed ratio of triglycerides to high-density lipoprotein (HDL)-cholesterol.
Method: The present case-control study included 30 T2DM males without lipid-lowering drugs and 25 apparently healthy males as a control group. After at least 8 hours overnight fasting, blood samples were drawn from each participant and analyzed to assess the fasting blood glucose, hemoglobin A1C, and lipid profile (low density lipoprotein, high density lipoprotein, total cholesterol, triglyceride).
Results: The comparison of the T2DM and control groups revealed that their ages matched, but that all studied factors differed significantly between the two groups (p≤0.05), with the exception of diastolic pressure. In addition to the strong correlation between the lipid profile and the AIP.
Conclusions: It was concluded that the AIP, a measure associated with improper metabolism of fats and carbohydrates, is crucial in characterizing the risk of atherogenicity and cardiometabolic defect in type II diabetes mellitus.
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References
Baynest HW. Classification, pathophysiology, diagnosis and management of diabetes mellitus. J Diabetes Metab. 2015;06(05). Doi:10.4172/2155-6156.1000541 DOI: https://doi.org/10.4172/2155-6156.1000541
Conget I. Diagnóstico, clasificación y patogenia de la diabetes mellitus [Diagnosis, classification and cathogenesis of diabetes mellitus]. Rev Esp Cardiol. 2002;55(5):528-35. Doi: 10.1016/s0300-8932(02)76646-3. DOI: https://doi.org/10.1016/S0300-8932(02)76646-3
Hoda SA, Hoda RS. Robbins and Cotran pathologic basis of disease. Adv Anat Pathol. 2005;12(2):103. Doi:10.1097/01.pap.0000155072.86944.7d DOI: https://doi.org/10.1097/01.pap.0000155072.86944.7d
Grundy SM, Benjamin IJ, Burke GL, Chait A, Eckel RH, Howard BV, et al. Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation. 1999 Sep 7;100(10):1134-46. doi: 10.1161/01.cir.100.10.1134. Erratum in: Circulation 2000;101(13):1629-31. Doi:10.1161/01.CIR.100.10.1134 DOI: https://doi.org/10.1161/01.CIR.100.10.1134
Aronson D, Edelman ER. Coronary artery disease and diabetes mellitus. Cardiol Clin. 2014;32(3):439-55. Doi: 10.1016/j.ccl.2014.04.001. DOI: https://doi.org/10.1016/j.ccl.2014.04.001
Mohammad AM, Jehangeer HI, Shaikhow SK. Prevalence and risk factors of premature coronary artery disease in patients undergoing coronary angiography in Kurdistan, Iraq. BMC Cardiovasc Disord. 2015;15(1):1-6. Doi: 10.1186/s12872-015-0145-7. DOI: https://doi.org/10.1186/s12872-015-0145-7
Feingold KR, Ahmed SF, Anawalt B, Blackman MR, Boyce A, Chrousos G, et al. Dyslipidemia in Patients with Diabetes. Endotext. South Dartmouth (MA): MDText.com, Inc.; 2023.
Florido R, Zhao D, Ndumele EN, Lutsey PL, McEvoy JW, Windham BG, et al. Physical activity, parental history of premature coronary heart disease, and incident atherosclerotic cardiovascular disease in the atherosclerosis risk in communities (ARIC) study. J Am Heart Assoc. 2016; 5(9):e003505. Doi.org/10.1161/JAHA.116.003505. DOI: https://doi.org/10.1161/JAHA.116.003505
Li Y, Feng Y, Li S, Ma Y, Lin J, Wan J and Zhao M The atherogenic index of plasma (AIP) is a predictor for the severity of coronary artery disease. Front. Cardiovasc. Med. 2023;10:1140215. Doi: 10.3389/fcvm.2023.1140215. eCollection 2023. DOI: https://doi.org/10.3389/fcvm.2023.1140215
Dobiasova M and Frohlich J. The plasma parameter log (TG/HDLC) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FERHDL). Clin Biochem. 2001;34(7):583- 588. Doi: 10.1016/s0009-9120(01)00263-6. DOI: https://doi.org/10.1016/S0009-9120(01)00263-6
Kavey REW, Daniels SR, Lauer RM, Atkins DL, Hayman LL, Taubert K; et al. American Heart Association guidelines for primary prevention of atherosclerotic cardiovascular disease beginning in childhood. Circulation, 2003; 107(11):1562-1566. Doi:10.1161/01.CIR.0000061521.15730.6E DOI: https://doi.org/10.1161/01.CIR.0000061521.15730.6E
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499-502. DOI: https://doi.org/10.1093/clinchem/18.6.499
Qin Z, Zhou K, Li Y, Cheng W, Wang Z, Wang J, et al. The atherogenic index of plasma plays an important role in predicting the prognosis of type 2 diabetic subjects undergoing percutaneous coronary intervention: results from an observational cohort study in China. Cardiovasc Diabetol. 2020;19:1-11. Doi: 10.1186/s12933-020-0989-8. DOI: https://doi.org/10.1186/s12933-020-0989-8
Li YW, Kao TW, Chang PK, Chen WL, Wu LW. Atherogenic index of plasma as predictors for metabolic syndrome, hypertension and diabetes mellitus in Taiwan citizens: a 9-year longitudinal study. Sci Rep. 2021;11(1):9900. Doi.org/10.1038/s41598-021-89307-z. DOI: https://doi.org/10.1038/s41598-021-89307-z
Onat A, Can G, Kaya H, Hergenç G. “Atherogenic index of plasma”(log10 triglyceride/high-density lipoprotein− cholesterol) predicts high blood pressure, diabetes, and vascular events. J Clin Lipidol. 2010;4(2):89-98. Doi: 10.1016/j.jacl.2010.02.005. DOI: https://doi.org/10.1016/j.jacl.2010.02.005
Okpa HO, Enang OE, Effa EE, Essien OE, Mbu PN. Comparative analysis of atherogenic index of plasma and its relationship with cardiovascular risk among patients with diabetes mellitus and concurrent diabetes mellitus with hypertension attending endocrinology clinic in a tertiary hospital south-south Nigeria. Atherosclerosis. 2015;13(15):16.Doi: 10.9790/0853-1488102107.
Fu L, Zhou Y, Sun J, et al. Atherogenic index of plasma is associated with major adverse cardiovascular events in patients with type 2 diabetes mellitus. Cardiovasc Diabetol. 2021;20(1):201.Doi: 10.1186/s12933-021-01393-5. DOI: https://doi.org/10.1186/s12933-021-01393-5
Anping C, Guang L, Jiyan C, Xida L, Liwen L, Yingling Z. Increased serum level of Lp-PLA2 is independently associated with the severity of coronary artery diseases: a cross-sectional study of Chinese population. BMC Cardiovasc Disord. 2015; 15:14. Doi: 10.1186/s12872-015-0001-9. DOI: https://doi.org/10.1186/s12872-015-0001-9
Jain HR, Shetty V, Singh GS, Shetty S. A study of lipid profile in diabetes mellitus. Int J Sci Study. 2016;4:56–61. Doi: 10.17354/ijss/2016/615
Ozder A. Lipid profile abnormalities seen in T2DM patients in primary healthcare in Turkey: a cross-sectional study. Lipids Health Dis. 2014;13:183. Doi:10.1186/1476-511X-13-183. DOI: https://doi.org/10.1186/1476-511X-13-183
Jayakumari C, Jabbar PK, Soumya S, et al. Lipid profile in Indian patients with type 2 diabetes: the scope for atherosclerotic cardiovascular disease risk reduction. Diabetes Spectr. 2020 Nov;33(4):299-306. Doi: 10.2337/ds19-0046. DOI: https://doi.org/10.2337/ds19-0046
Chen L, Pei JH, Kuang J, et al. Effect of lifestyle intervention in patients with type 2 diabetes: a meta-analysis. Metabolism. 2015;64:338–347. Doi: 10.1016/j.metabol.2014.10.018. DOI: https://doi.org/10.1016/j.metabol.2014.10.018
Lin X, Zhang X, Guo J, et al. Effects of exercise training on cardiorespiratory fitness and biomarkers of cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials. J Am Heart Assoc. 2015;4:4. Doi: 10.1161/JAHA.115.002014. DOI: https://doi.org/10.1161/JAHA.115.002014
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Copyright (c) 2025 Suhaer Zeki Al-Fadhel, Nibras H. Abdulsada, Shaden M H Mubarak, mohauman mohammed majeed
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