Aplicación de la tecnología de impresión en 3D para la formulación farmacéutica de flavonoides

Ivo Heyerdahl-Viau

doi:10.30827/ars.v66i2.31923

Authors

Ivo Heyerdahl-Viau Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana Unidad Xochimilco, Ciudad de México, México https://orcid.org/0000-0002-8252-2552

DOI:

https://doi.org/10.30827/ars.v66i2.31923

Keywords:

Flavonoids, Three-Dimensional Printing, Drug Compounding

Abstract

Introduction: 3D printing is an advanced technology that can be used to formulate pharmaceutical compounds with low solubility, such as flavonoids—plant-derived compounds to which various pharmacological effects have been attributed. This review describes studies in which this technology has been applied to formulate flavonoids into different pharmaceutical forms.

Methodology: A bibliographic review was conducted by searching databases such as Google Scholar and PubMed search engine up to January 2025, using the keywords “3D printing,” “flavonoids,” and “formulation.” Original articles published in English were selected.

Results: Five articles were found. In these studies, the flavonoids puerarin, catechin, apigenin, and quercetin were formulated. Puerarin, a flavonoid with cardiovascular effects, was used in gastric floating tablets that extended its stomach retention time and improved its release compared to conventional tablets. For catechin and apigenin (flavonoids with antioxidant and anticancer properties, respectively), oral mucoadhesive films were designed, allowing rapid local absorption for the treatment of oral ulcers and leukoplakia, respectively. Quercetin, known for its antimicrobial activity against Mycobacterium tuberculosis, was formulated into dermal patches that achieved sustained drug release for 70 hours in in vitro studies and maintained stable plasma levels for up to 18 days in animal models.

Conclusion: 3D printing has been successfully used to formulate flavonoids into different pharmaceutical forms, significantly improving their biopharmaceutical properties. However, this is basic research, therefore, it is important to conduct formal preclinical trials to benefit real patients, including veterinary patients.

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References

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