Formulation, Development, and Evaluation of Flubiprofen Sustained Release Tablets Using a Quality-by-Design Approach
DOI:
https://doi.org/10.30827/ars.v66i2.31527Keywords:
Flubiprofen, Sustained release, Dissolution, Polymer, DOE, Quality by DesignAbstract
Introduction: Flurbiprofen acts by blocking the cyclooxygenase (COX) enzymes in your body from carrying out their normal function. The study made flubiprofen tablets that last a long time by directly compressing them with carbopol, HPMC K100M, and HPMC K4M polymers. An anti-inflammatory non-steroid is flubiprofen.
Method: The research formulates and develops sustained-release flubiprofen tablets by direct compression with carbopol, HPMC K100M, and HPMC K4M polymers. The highest flubiprofen concentration in ethanol, according to pre-formulation tests, was 215 nm.
Results: The compressibility tablet was tested for thickness, diameter, medication content, and friability. Every exam was good. The compressibility index, bulk density, angle of repose, and tapped density showed good results for the tablet mix. In-vitro release tests were performed utilizing a USP device type II at 50 RPM, 0.1 N HCl in the dissolving media for two hours, and phosphate buffer pH 6.8 for six hours at 37 +0.5°C. A UV-visible spectrophotometer with a 215 nm setting assessed drug release at different periods. This formulation research indicated 99.25 % drug release from F2.
Conclusions: One benefit of the sustained release dosage form is that it allows a medication to be administered gradually over an extended period in order to keep the blood level of concentration constant. This may improve patient compliance and increase drug output.
Downloads
References
Jadhav KR, Ambade KW, Jadhav SL, Gambhire MN, Kurmi SD, Kadam VJ. Formulation and evaluation of flurbiprofen microemulsion. Curr Drug Deliv. 2008; 5(1):32-41. Doi: 10.2174/156720108783331032 DOI: https://doi.org/10.2174/156720108783331032
Kumar S. Proniosomal gel of flurbiprofen: formulation and evaluation. J drug Deliv Therap. 2012;2(1). Doi: 10.22270/jddt.v2i1.31 DOI: https://doi.org/10.22270/jddt.v2i1.31
Mettu SR, Veerareddy PR. Formulation, evaluation and pharmacokinetics of flurbiprofen fast dissolving tablets. Brit J Pharm Res. 2013;3(4):617-31. DOI: https://doi.org/10.9734/BJPR/2014/3979
Swain RP, Kumari TR, Panda SA. Formulation development and evaluation of sustained release ibuprofen tablets with acrylic polymers (eudragit) and HPMC. Int J Pharm Pharmaceut Sci. 2016;8(2):131-5.
Radhika PR, Pal TK, Sivakumar T. Formulation and Evaluation of Sustained Release Matrix Tablets of Glipizide: Sustained release matrix tablets of glipizide. Iran J Pharm Sci. 2009; 5(4):205-14. Doi: 10.22037/ijps.v5.41224
Bhowmik D, Yadav R, Jayakar B, Kumar KS. Formulation and evaluation the oral tablets ibuprofen. The Pharma Innovation. 2012;1(9, Part A):32. Doi: NA
Ratnaparkhi MP, Gupta Jyoti P. Sustained release oral drug delivery system-an overview. Terminol. 2013;3(4):10-22270.
Bakre LG, Akinyele E, Bamiro O, Adeleye O, Kunle O. Formulation and evaluation of sustained release ibuprofen matrix tablets using starch from maize genotypes as polymer. Acta Marisiensis-Seria Medica. 2021;67(2):122-6. Doi: 10.2478/amma-2021-0018 DOI: https://doi.org/10.2478/amma-2021-0018
Sharma V, Sharma S, Khokra SL, Sahu RK, Jangde R, Singh J. Formulation, development and evaluation of Pregabalin sustained release matrix tablets. Der Pharmacia Lettre. 2011;3(5):326-3.
Dabbagh MA, Beitmashal L. Sustained release formulation and in-vitro evaluation of ibuprofen-hpmc matrix tablets. Jundishapur J Nat Pharm Prod. 2006 Dec 20;1(1):1-7.
Joshi RS, Nangare AK, Sanap DS, Sase SM. Development and Validation of UV-Spectrophotometric Method for Estimation of Metformin Hydrochloride and Pioglitazone in Tablet Dosage Form. J Drug Deliv and Therap. 2019 Aug 30;9(4-A):381-4. Doi: 10.22270/jddt.v9i4-A.3499 DOI: https://doi.org/10.22270/jddt.v9i4-A.3499
Lopes CM, Manuel Sousa Lobo J, Costa P, Pinto JF. Directly compressed mini matrix tablets containing ibuprofen: preparation and evaluation of sustained release. Drug Dev Ind Pharm. 2006;32(1):95-106. Doi: 10.1080/03639040500388482 DOI: https://doi.org/10.1080/03639040500388482
Sahilhusen IJ, Mukesh RP, Alpesh DP. Sustained release drug delivery systems: A patent overview. Aperito J Drug Desig a Pharmacol. 2014 Oct;1(1):1-4.
Alhalmi A, Altowairi M, Saeed O, Alzubaidi N, Almoiliqy M, Abdulmalik W. Sustained release matrix system: an overview. World J Pharm Pharm Sci. 2018; 7(6):1470-86.
Almeida H, Amaral MH, Lobão P. Prolonged-release solid dispersions of ibuprofen. J Appl Pharm Sci. 2012; 2(6):67-70. DOI: 10.7324/JAPS.2012.2603 DOI: https://doi.org/10.7324/JAPS.2012.2603
Bhowmik D, Yadav R, Jayakar B, Kumar KS. Formulation and evaluation the oral tablets ibuprofen. The Pharma Innovation. 2012 Nov 1;1(9, Part A):32.
Uddin M, Halder S, Kumar U, Rouf AS. Design and evaluation of once daily losartan potassium sustained release matrix tablet. Int J Pharm Sci Res. 2014;5(2):519. Doi: 10.13040/IJPSR.0975-8232.5(2).519-25 DOI: https://doi.org/10.13040/IJPSR.0975-8232.5(2).519-25
Guerra-Ponce WL, Gracia-Vásquez SL, González-Barranco P, Camacho-Mora IA, Gracia-Vásquez YA, Orozco-Beltrán E, Felton LA. In vitro evaluation of sustained released matrix tablets containing ibuprofen: a model poorly water-soluble drug. Braz J Pharm Sci. 2016; 52: 751-9. Doi: 10.1590/S1984-82502016000400020
Hapse SA, Kadaskar PT, Shirsath AS. Difference spectrophotometric estimation and validation of ibuprofen from bulk and tablet dosage form. Der Pharmacia Lettre. 2011;3(6):18-23.
Patil SJ, Surana KR, Mahajan SK. Quantification of active phytoconstituents in ethanolic extract of Mentha piperita by modern analytical tools. Res Jr Agril Sci. 2024; 15(3): 615-21.
Patil SJ, Surana KR, Mahajan SK. In vitro antimicrobial and antifungal activity of Mentha piperita active phytoconstituents. Res Jr Agril Sci. 2023; 14(6): 1875-7.
Sonawane VN, Suryawanshi KG, Wagh KH, Sonawane SL, Sonar AD, Sakle SJ, Sonawane DD. A Comparative Study of Dissolution Profiles on Various Brands of Diclofenac Sodium Prolonged Release Tablet Formulation. Prog Chem Biochem Res. 2023; 6(4):341-55. Doi: 10.48309/pcbr.2023.410170.1271
Patel N, Madan P, Lin S. Development and evaluation of controlled release ibuprofen matrix tablets by direct compression technique. Pharm Develop Tech. 2011;16(1):1-1.Doi: 10.3109/10837450903460467 DOI: https://doi.org/10.3109/10837450903460467
Lakio S, Tajarobi P, Wikström H, Fransson M, Arnehed J, Ervasti T, Simonaho SP, Ketolainen J, Folestad S, Abrahmsén-Alami S. Achieving a robust drug release from extended release tablets using an integrated continuous mixing and direct compression line. Int J Pharma. 2016; 511(1):659-68. Doi: 10.1016/j.ijpharm.2016.07.052 DOI: https://doi.org/10.1016/j.ijpharm.2016.07.052
Wahab A, Khan GM, Akhlaq M, Khan NR, Hussain A, Zeb A, Rehman A, Shah KU. Pre-formulation investigation and in vitro evaluation of directly compressed ibuprofen-ethocel oral controlled release matrix tablets: A kinetic approach. Afr J Pharmacy Pharmacol. 2011;5(19):2118-27. Doi: 10.5897/AJPP11.128 DOI: https://doi.org/10.5897/AJPP11.128
Modi A, Pandey A, Singh V, Bonde CG, Jain D, Shinde S. Formulation and evaluation of fast dissolving tablets of diclofenac sodium using different superdisintegrants by direct compression method. Pharmacia. 2012; 1(3):95-101.
Guerra-Ponce WL, Gracia-Vásquez SL, González-Barranco P, Camacho-Mora IA, Gracia-Vásquez YA, Orozco-Beltrán E, Felton LA. In vitro evaluation of sustained released matrix tablets containing ibuprofen: a model poorly water-soluble drug. Braz J Pharm Sci. 2016; 52:751-9. Doi: 10.1590/S1984-82502016000400020 DOI: https://doi.org/10.1590/s1984-82502016000400020
Gil-Chávez J, Padhi SS, Leopold CS, Smirnova I. Application of Aquasolv Lignin in ibuprofen-loaded pharmaceutical formulations obtained via direct compression and wet granulation. Int J Biol Macromol. 2021; 174:229-39. Doi: 10.1016/j.ijbiomac.2021.01.064 DOI: https://doi.org/10.1016/j.ijbiomac.2021.01.064
Ervasti T, Simonaho SP, Ketolainen J, Forsberg P, Fransson M, Wikström H, Folestad S, Lakio S, Tajarobi P, Abrahmsén-Alami S. Continuous manufacturing of extended release tablets via powder mixing and direct compression. Int J Pharma. 2015; 495(1):290-301.Doi: 10.1016/j.ijpharm.2015.08.077 DOI: https://doi.org/10.1016/j.ijpharm.2015.08.077
Wiranidchapong C, Ruangpayungsak N, Suwattanasuk P, Shuwisitkul D, Tanvichien S. Plasticizing effect of ibuprofen induced an alteration of drug released from Kollidon SR matrices produced by direct compression. Drug Dev Ind Pharm 2015;41(6):1037-46. Doi: 10.3109/03639045.2014.925917 DOI: https://doi.org/10.3109/03639045.2014.925917
Wei Q, Yang F, Luan L. Preparation and in vitro/in vivo evaluation of a ketoprofen orally disintegrating/sustained release tablet. Drug Dev Ind Pharm. 2013; 39(6):928-34. Doi: 10.3109/03639045.2012.664146 DOI: https://doi.org/10.3109/03639045.2012.664146
Shittu AO, Njinga SN, Joshua A. Formulation and Evaluation of Fast Disintegrating Oral Tablets of Ibuprofen using Mannitol, PEG 4000, Cellactose and Sodium Starch Glycolate via Direct Compression: https://doi. org/10.51412/psnnjp. 2022.32. Niger J Pharm. 2022; 56(2). Doi: 10.51412/psnnjp.2022.32 DOI: https://doi.org/10.51412/psnnjp.2022.32
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Khemchand Surana, Rutuja Deore, Rushikesh Bachhav, Sunil Mahajan, Deepak Sonawane
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The articles, which are published in this journal, are subject to the following terms in relation to the rights of patrimonial or exploitation:
- The authors will keep their copyright and guarantee to the journal the right of first publication of their work, which will be distributed with a Creative Commons BY-NC-SA 4.0 license that allows third parties to reuse the work whenever its author, quote the original source and do not make commercial use of it.
b. The authors may adopt other non-exclusive licensing agreements for the distribution of the published version of the work (e.g., deposit it in an institutional telematic file or publish it in a monographic volume) provided that the original source of its publication is indicated.
c. Authors are allowed and advised to disseminate their work through the Internet (e.g. in institutional repositories or on their website) before and during the submission process, which can produce interesting exchanges and increase citations of the published work. (See The effect of open access).
