The Effect of Pharmaceutical Intervention on Therapeutic Adherence, Viral Load, and CD4 T Lymphocyte Count in Human Immunodeficiency Virus: An Observational Study in a Hospital Setting
DOI:
https://doi.org/10.30827/ars.v65i4.30874Keywords:
HIV, pharmaceutical services, treatment adherence and complianceAbstract
Introduction: To analyze the effect of pharmaceutical intervention on therapeutic adherence, viral load (VL), and CD4 T lymphocyte count in human immunodeficiency virus (HIV) for strengthening the role of the pharmacist in an infectious diseases service.
Methods: Retrospective observational study. Data were collected through interviews using the “Assessment of Predictive Factors of Therapeutic Adherence” questionnaire. VL and CD4 parameters were collected f were collected from the patients’ medical records at the hospital.
Results: 103 patients were included, 92 % men, mean age 32.30± 10.90 years for the group of patients. After pharmaceutical intervention through strategies to promote adherence: 100 % of patients increased their knowledge of their disease, 62 % increased their knowledge of antiretroviral therapy (ART), 90 % showed tolerance to ART, and 4 % experienced adverse reactions. This was reflected in an increase in the median CD4 T lymphocyte count and a decrease in viral load (undetectable in 72 % of patients), statistically and clinically significant results (p< 0.01).
Conclusions: The findings suggest that pharmaceutical intervention in therapeutic adherence to ART has beneficial effects (CD4 and VL) in the analyzed patient group. Further studies are necessary.
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Bekker L, Beyrer C, Mgodi N, Lewin SR, Delany-Moretlwe S, Taiwo B, et al. HIV infection [published correction appears in Nat Rev Dis Primers. 2023;9(1):48]. Nat Rev Dis Primers. 2023;9(1):42. doi:10.1038/s41572-023-00452-3
Ahmed A, Abdulelah Dujaili J, Rehman IU, Chuah LH, Hashmi FK, Awaisu A, et al. Effect of pharmacist care on clinical outcomes among people living with HIV/AIDS: A systematic review and meta-analysis. Res Social Adm Pharm. 2022;18(6):2962-2980. doi:10.1016/j.sapharm.2021.07.020
Ambrosioni J, Levi L, Alagaratnam J, Van Bremen K, Mastrangelo A, Waalewijn H,et al. Major revision version 12.0 of the European AIDS Clinical Society guidelines 2023. HIV Med. 2023;24(11):1126-1136. doi:10.1111/hiv.13542
Ryom L, De Miguel R, Cotter AG, Podlekareva D, Beguelin C, Waalewijn H, et al. Major revision version 11.0 of the European AIDS Clinical Society Guidelines 2021. HIV Med. 2022;23(8):849-858. doi:10.1111/hiv.13268
Yona S, Edison C, Nursasi AY, Ismail R. Self-awareness as the key to successful adherence to antiretroviral therapy among people living with HIV in Indonesia: A grounded theory study. Belitung Nurs J. 2023;9(2):176-183. doi:10.33546/bnj.2480
Ahmed A, Tanveer M, Dujaili JA, Chuah LH, Hashmi FK, Awaisu A. Pharmacist-Involved Antiretroviral Stewardship Programs in People Living with HIV/AIDS: A Systematic Review. AIDS Patient Care STDS. 2023;37(1):31-52. doi:10.1089/apc.2022.0192
Abadiga M, Hasen T, Mosisa G, Abdisa E. Adherence to antiretroviral therapy and associated factors among Human immunodeficiency virus positive patients accessing treatment at Nekemte referral hospital, west Ethiopia, 2019. PLoS One. 2020;15(5):e0232703. doi:10.1371/journal.pone.0232703.
Whiteley LB, Olsen EM, Haubrick KK, Odoom E, Tarantino N, Brown LK. A Review of Interventions to Enhance HIV Medication Adherence [published correction appears in Curr HIV/AIDS Rep. 2021 Sep 15]. Curr HIV/AIDS Rep. 2021;18(5):443-457. doi:10.1007/s11904-021-00568-9
Cunha GH, Galvão MT, Pinheiro PN, Vieira NF. Health literacy for people living with HIV/Aids: an integrative review. Rev Bras Enferm. 2017;70(1):180-188. doi:10.1590/0034-7167-2015-0052
Mgbako O, Conard R, Mellins CA, Dacus JD, Remien RH. A Systematic Review of Factors Critical for HIV Health Literacy, ART Adherence and Retention in Care in the U.S. for Racial and Ethnic Minorities. AIDS Behav. 2022;26(11):3480-3493. doi:10.1007/s10461-022-03680-y
Isika AI, Shehu A, Dahiru T, Obi IF, Oku AO, Balogun MS, et al. Factors influencing adherence to antiretroviral therapy among HIV-infected adults in cross river state, Nigeria: A cross-sectional study. Pan Afr Med J. 2022;43:187.
Tafur Valderrama E, Ortiz Alfaro C, García-Jiménez E, Faus Dader M, Martínez Martínez F. Impacto de la intervención farmacéutica en la adherencia al tratamiento antirretroviral en pacientes de un hospital de Lima (Perú). Pharm Care Esp. 2012;14(4):146.
Arrieta-Martínez JA, Estrada-Acevedo JI, Gómez Carlos A, Madrigal-Cadavid J, Serna-Juan A, Giraldo PA, et al . Factores relacionados con la no adherencia a la terapia antirretroviral en pacientes con VIH/sida. Farm Hosp. 2022;46(6): 319-326.
Hadaye RS, Jambhale VB, Shastri S. Assessment of adherence and factors contributing to non-adherence among patients on anti-retroviral therapy in a tertiary care hospital: A cross sectional study. J Family Med Prim Care. 2020;9(4):1921-1926. doi:10.4103/jfmpc.jfmpc_1138_19
Caja Costarricense de Seguro Social. Instructivo para la aplicación del instrumento Valoración de Factores Predictivos de Adherencia Terapéutica. San José, Costa Rica: CCSS; 2014
Caja Costarricense de Seguro Social. Política institucional de Atención Farmacéutica. San José, Costa Rica: CCSS; 2012
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