Preclinical evaluation of the anti-inflammatory activity of a gel with tea tree oil
DOI:
https://doi.org/10.30827/ars.v65i1.29152Keywords:
Antiinflammatory agents, periodontal disease, phytotherapy, tea tree oil, preclinical drug evaluationAbstract
Objective: To evaluate the anti-inflammatory activity of a semi-solid Tea Tree Oil (TTO) form at 2 % and 2,5% concentrations for treating periodontal disease.
Method: A preclinical test in a sample of 30 mice with ear edema induced by croton oil was divided into two groups to compare treatment with Indomethacin and Diclofenac.
Results: TTO at 2,5 % concentration showed a higher inhibition activity of inflammation (54,74 %) than TTO at 2 % (51,21 %). Statistical analysis showed no significative differences between treatment combinations (p>0,05).
Conclusions: The tea tree oil in semi-solid form, applied in 2 - 2,5 % concentration in this preclinical study, showed consistent anti-inflammatory activity.
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