Neocuproine-Based Sensitive Flow Injection Method for Mefenamic Acid Determination in Aqueous Solutions and Pharmaceutical Formulations
DOI:
https://doi.org/10.30827/ars.v65i1.28908Keywords:
Continues Flow İnjection Analysis; Mefenamic Acid; NeocuproineAbstract
Introduction: A novel and precise approach is presented for the mefenamic acid (MEF) estimation in pharmaceutical formulations and aqueous solutions, utilizing flow injection spectrophotometry. Similarly, this method demonstrates a high level of sensitivity and accuracy.
Method: The suggested method is based on the reducing of Cu(II)-2,9DMP complex to coloured Cu(I)- 2,9DMP complex ,by two step of reaction. However, in the first step the reaction is occur between neocuproine and Cu(ΙΙ) to form colorless complex of Cu(II)-2,9DMP, then in second step mefenamic acid reduced the formed colorless complex to Cu(I)- 2,9DMP with yellow orange colour, Flow Injection Method were developed and validated.
Results: The measurement of the optical density of the yellow-orange substances was conducted at a wavelength of 454 nm. The calibration graphs exhibit linearity within the specified concentration ranges of 1.00-80.00 µg/mL. The detection limit (LOD) is determined to be 0.360 µg/ mL, while the limit of quantification (LOQ) is found to be 1.093 µg/ mL.
Conclusions: the proposed methodology exhibited notable attributes such as rapidity, sensitivity, and reliability, rendering it suitable for the accurate quantification of (MEF) in pharmaceutical formulations and aqueous solutions in various commercially available formulations.
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