Liposomes in pharmaceutical semisolid dosage forms
DOI:
https://doi.org/10.30827/ars.v63i4.26059Keywords:
liposomes, skin, semisolid dosage forms, nanotechnology, dermis, dermal penetrationAbstract
Introduction: liposomes are spherical phospholipid nanovesicles, an essential characteristic for their permeability. Hence, they are widely used as drug delivery systems for dermal and transdermal administration.
Method: a bibliographic review of scientific articles and patents published on different information sources was carried out. We reviewed Google Scholar, Google Patents, Pubmed, Elsevier, ScienceDirect, Scielo, and specialized journals, both in English and Spanish. The articles were published between 2012 and 2022, and the most relevant were selected.
Results: in total, 31 articles and 9 patents were selected, to be evaluated and analyzed. These articles demonstrate the use of liposomes in semisolid dosage forms of various pharmacological categories, such as non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, opioid analgesics, local anesthetics, antibiotics, antifungals, antivirals, antimetabolites, vitamins, phytochemicals, and some cases of skin pathologies treatment.
Conclusions: nanotechnology and its advances are especially interesting for drug formulation. The use of liposomal systems has become a useful tool, which is beneficial, due to its characteristics, for the formulation of semi-solid dosage forms.
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