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Abstract
Nucleotides play key roles in all living organisms. The diet contains relatively high levels of free nucleotides and nucleic acids which can be used as building blocks for cell nucleotides mainly in tissues with a rapid tumover. Human milk represents the exclusive source of nucleotides in early life. In this period nucleotides inhance the bioavailability of iron and stimulate the growth of intestinal bifidobacteria limiting that of enterobacteria. Moreover, dietary nucleotides increase high density lipoprotéins levels and Apo A-I and Apo A-IV in newbom infants. Furthermore, dietary nucleotides modulate the immune system both in experimental animals and humans stiIpulating the lymphoproliferative response of T cells against mitogens and enhancing the in vivo and in vitro production of immunoglobulins. In addition, dietary nucleotides are preferently utilized in tissue repair after injury particularly in those tissues exhibiting a high tumover. Thus, nucleotides improve the small intestinal repair after a process of chronic diarrhoea and malnutrition and reduce the prevalence and duration of chronic diarrhoea in infants. Moreover, they increase the recovery of hepatic lessions induced by the intake of thioacetamide in experimental animals.
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