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Abstract
Gluconeogenesis is defmed as the metabolic process by which glucose is sinthetized from non-glucidic precursors such as pyruvate, lactate, glycerol and a great number of aminoacids. In mammals, this process mainly talee place in liver and renal cortex. Tradicionally, the liver has been considered as the main responsible tissue in the maintenance in glycaemic homeostasis, whereas the renal cortex only provide glucose to the whole animal in a small and constant amount without significanta adaptive changes. Nevertheless, during the last years it has been pointed out that renal tissue is able to adapt itself to different organic conditions characterized by hepatic metabolic failure or when the exogenous availability of macronutrients changes significantly. In this review, it is summarized the adaptive mechanisms of different metabilic pathways that talee place in these tissues under the nutritional and hormonal conditions dominant in each moment.
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