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Abstract
The effects of several different nutritional conditions on rat-kidney-cortex glucose 6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) activities have been studied. Neither lipogenic (high-carbohydrate diet) nor lipolityc (fast and high-fat diet) conditions modified the enzymes activities. Only the high-protein diet produced a significant increase on both renal G6PDH and 6PGDH actlvltles about 60-70 % respectively. These changes were significant as well at saturant as subsaturant substrate concentrations after eight days of treatment. The enhanced enzyme activity are in agreement with variations in the cellular concentration of these enzymes. Finally, the reasons of this induction was analized and the different aspects of renal nutritional regulation of pentose phosphate pathway have been discussed.
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