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Abstract
The influence of an inhibitor of the paracellular pathways (2, 4, 6 Triaminopirimidine, T AP) on the movemente of water and electrolytes, in distal ileum and proximal colon of rabbit "in vitro" and "in vivo", have been studied. "In vitro" the TAP significantly decreased the absorption of sodium, chloride and raised the secretion of potassium, reversing the transference of
bicarbonate to the secretion, both in ileum and colon. "In vivo" the T AP at ileal level had a similar effect than "in vitro", although the differences were less important. In the colon the changes were just the opposite, but they were no significative differences.
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