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Abstract
The different effects of various sympathomimetic drugs on acetylcholine- and CaCl2 -produced contractions in mammalian trachea preparations (rat, guinea pig and New Zealand rabbit) were studied. The most noteworthy response was that rat tracheas failed to respond to β-receptors, in view of the absence of isoprenaline (a β-agonist) activity in these preparations. Some α-simulating drugs showed relaxant effects, oxymetazoline being particularly active in all three species studied. This relaxant effect was not related to adrenergic receptors and can presumably be traced to some indirect mechanism.
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