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Abstract
The evolution of the effect of the administration of hydrocortisone acetate (HA) (4mg/100g weightlday) to the pregnant rat on the number of viable and nonviable fetuses was studied on days 6, 9, 12, 14, 16, 18 and 21 of gestation. The administration of HA to pregnant rats reduced the number of live fetuses starting on day 17 of treatment representing a loss of approximately 25% of the fetuses when they are compared with the control rats. High doses of cortisone acetate were seen to increase the percentage of rats whose uterus contained dead fetuses at any given period of study. On day 14 more over the entire litter was found to have died in utero in 22,2% of all cortisol injected rats, a finding which never occurred in controls. The effects of cortisol were most in evidence on day 21, when all fetuses were viable in controls as opposed to hormone-treated rats, 66% of which were found to contain nonviable fetuses.
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