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Abstract
In the present work a study on the bioavailibity of three fluorate corticoids contained in various semisolid preparations have been carried out. The medicinal substance submítted to the assay, Flupamesona, Fluprednyliden y Formocortal, have been included in two usual excipients, the Hydrophilic Ointment and the Polyethyleneglycol. Furthermore, three commercial formulations in whích they are contained, were assayed. The test carried out in all of them are of two kinds:
- "In vitro", following the technique of cession in isopropyl myristate.
- "In vivo", following the procedure of vasoconstricción and bleaching of McKENZIE and STOUGHTON.
From the results obtained we verify that the Hydrophilic Ointment shows better properUes of cession, even better than the formulations which are available in the pharmaceutical market. Likewise, from the three corticoids assayed, the Fomocortal shows a greater vasoconstricting activity, being followed by the Fluprednyliden; the Flupamesona is found in the last position.
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