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Abstract

Levofloxacin is an antibacterial agent of the fluoroquinolones group. The absorption and disposition kinetics of levofloxacin were investigated following single oral dose 500-mg tablet in 26 healthy young male volunteers. The study revealed mean ± SD value of Tmax 2.08 ± 0.84 h, Cmax 4.79 ± 1.40 μg/mL, total body clearance 10.8 ± 4.60 L.h-1 and apparent volume of distribution (Vd) 109 ± 64 L indicating extensive tissue distribution. Elimination half-life of the drug in plasma was 6.86 ± 2.12 h. Following verification of pharmacokinetics parameters in normal subjects, an appraisal of manufacturer's recommended dosage regimen in clinical conditions and therapeutic monitoring is appropriate for optimal application of this fluoroquinolone.

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Published

2000-03-20

How to Cite

1.
Español, Español. English. Ars Pharm [Internet]. 2000 Mar. 20 [cited 2024 May 12];41(2):183-7. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/24719

Issue

Vol. 41 No. 2 (2000)

Section

Original Articles

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