Magnesium homeostasis and its role in the exocrlne pancreas

Authors

  • Español
  • Español

Keywords:

Español

Abstract

Magnesium is an abltlldant divalent cation that plays an important physiological and biochemical role at different levels. lt is in volved in several physiological processes during cellular regulation, so it is important to understand the homeostasis of this cation in the pancreas. This study shows the role of magnesium in the pancreas acting on the regulation of insulin secretion, altering pancreatic and blood histamine levels, and on the ability of acinar cells to synthesize new proteins. lt is also reported the effect of a perturbation of extracellular magnesium on the pancreatic enzyme, protein, and juice secretion in response to acetylcholine, cholecystokinin-octapeptide and activation of intrinsic secreto motor nerves. We have shown the distribution of magnesium within pancreatic acinar cells, focusing on the transport mechanisms for this cation in the exocrine pancreas, which we ha ve examined by means of several techniques. Finally, our results have demonstrated that magnesium may play an important regulatory role in the mobilization of
calcium during the exocytotic process in the exocrine pancreas.

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Published

1999-06-20

How to Cite

1.
Español, Español. Magnesium homeostasis and its role in the exocrlne pancreas. Ars Pharm [Internet]. 1999 Jun. 20 [cited 2024 May 17];40(3):165-71. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/24701

Issue

Vol. 40 No. 3 (1999)

Section

Original Articles

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