Cyclodextrins: properties and applications of inclusion complex formation
Abstract
Cyclodextrins are macrocyclic compounds consisting of a varying number of D(+)
glucopiranose residues linked through a(1-4) bonds. The most widely used are a-, 13-, ycyclodextrins
containing respectively 6,7 and 8 glucose units. In spite of their high
aqueous solubility, the inner cyclodextrin cavity is non-polar and they can form complexes
with many types of molecules placed inside this cavity. Most industrial applications of
cyclodextrins aim at improving certain properties offmished products (solubility, organoleptic
properties, stability). In this article several applications of cyclodextrins to pharmaceutical
industry and chemical catalysis are reviewed. Analytical applications are al so considered,
since cyclodextrin inclusion improves the sensitivity and selectivity of most analytical methods.
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