Cyclodextrins: properties and applications of inclusion complex formation

Authors

  • M. A. MARTÍN

Abstract

Cyclodextrins are macrocyclic compounds consisting of a varying number of D(+)

glucopiranose residues linked through a(1-4) bonds. The most widely used are a-, 13-, ycyclodextrins

containing respectively 6,7 and 8 glucose units. In spite of their high

aqueous solubility, the inner cyclodextrin cavity is non-polar and they can form complexes

with many types of molecules placed inside this cavity. Most industrial applications of

cyclodextrins aim at improving certain properties offmished products (solubility, organoleptic

properties, stability). In this article several applications of cyclodextrins to pharmaceutical

industry and chemical catalysis are reviewed. Analytical applications are al so considered,

since cyclodextrin inclusion improves the sensitivity and selectivity of most analytical methods.

Downloads

Download data is not yet available.

References

SCHARDINGER, F.: Z. Unters. Nahr. Genussm. (1903), 6:865-880.
SCHARDINGER, F.: Wien. Klin. Wochenschr. (1904), 17:207-209.

FREUDENBERG, K. and CRAMER, F.: Chem. Ber. (1950), 83:296-304.

BORCHERT, W.: Heidelberg Beitr. Mineral. (1952),3:1 24-130.

FRENCH, D.: Adv. Carbohyd. Chem. (1957), 12:189-260.

SAENGER, W.: Angew. Chem. Int. Ed. Engl. (1980), 19:344-362.

SICARD, P. J. and SANIEZ, M. H.: "Biosynthesis of Cycloglycosiltransferase and
Obtention ofIts Enzimatic Reaction Products", en Duchene, D. (Ed.): "Cyclodextrins and
their industrials uses" (1987), p. 75 , Editions de Santé, Paris.

CRAMER, F.: Chem. Ber. (1951), 84:855-859.

DIETRICH, H. V. and CRAMER, F.: Chem. Ber. (1954), 87:806-817.

SAENGER, W.: Angew. Chem. (1980), 19:344-362.

SZEJTLI, J., SZENTE, L. and BANK.Y-ELÓD, E.: Acta Chim. Acad. Sci. Hung. (1979),
101:27-46.

SZENTE, L., APÓSTOL, 1. and SZEJTLI, J.: Pharmazie (1985), 39:697-699.

SZEJTLI, J., BOLLA-PUTSZTAI, E., SZABO, P. and FERENCZY, T. Pharmazie (1980),
35:779-787.

SZEJTLI, J., BOLLA-PUTSZTAI, E. and KAJATAR, M.: Pharmazie (1982), 37:725-
728.

NAKAI, Y., YAMAMOTO, K., TERADA, K. and AKIMOTO, K.: Chem. Pharm. Bull.
(1984), 32:685-69l.

M0LLGAARD ANDERSEN, F. and BUNDGAARD, H.: Arch. Pharm. Chem. Sci. Ed.
(1982), 10:80-87.

RAMADA, Y., NAMBU, N. and NAGAI, T.: Chem. Pharm. Bull. (1975),23:1205-1211.

M0LLGAARD ANDERSEN, F. and BUNDGAARD, H.: Int. J. Pharm. (1984), 19:189-
197.

Downloads

Published

1995-06-20

How to Cite

1.
MARTÍN MA. Cyclodextrins: properties and applications of inclusion complex formation. Ars Pharm [Internet]. 1995 Jun. 20 [cited 2024 Aug. 24];36(2):187-98. Available from: https://revistaseug.ugr.es/index.php/ars/article/view/21904

Issue

Vol. 36 No. 2 (1995)

Section

Original Articles

License

The articles, which are published in this journal, are subject to the following terms in relation to the rights of patrimonial or exploitation:

  1. The authors will keep their copyright and guarantee to the journal the right of first publication of their work, which will be distributed with a Creative Commons BY-NC-SA 4.0 license that allows third parties to reuse the work whenever its author, quote the original source and do not make commercial use of it.

b. The authors may adopt other non-exclusive licensing agreements for the distribution of the published version of the work (e.g., deposit it in an institutional telematic file or publish it in a monographic volume) provided that the original source of its publication is indicated.

c. Authors are allowed and advised to disseminate their work through the Internet (e.g. in institutional repositories or on their website) before and during the submission process, which can produce interesting exchanges and increase citations of the published work. (See The effect of open access).