Investigaciones actuales en ligandos de receptores opiáceos
Abstract
En los últimos veinte años se ha llevado a cabo una intensa investigación sobre la
búsqueda de agonistas y antagonistas selectivos de cada subtipo de receptores opiáceos.
Recientemente, se han sintetizado nuevos derivados benzomorfánicos y compuestos con
restos ciclopropilmetílicos sobre N-l que muestran alta afinidad y selectividad por los
receptores K . Los compuestos MPCB y CCB se han seleccionado como agonistas específicos
- La afinidad de CCB es dos veces mayor que la del compuesto USO,488H. De
estos compuestos se han derivado interesantes compuestos con estructura de peptidoheterocido
y se han obtenido importantes informaciones sobre los procesos de binding a
los receptores K.
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