Advances in antiseptic formulations
DOI:
https://doi.org/10.30827/ars.v62i4.21804Keywords:
Antiseptics; pharmaceutical form; nanoparticles; SEDDS, film-forming systemsAbstract
Objective: To review new antiseptic formulations that minimize the drawbacks of conventional formulations and improve the effectiveness of currently used treatments.
Methodology: A bibliographic search was carried out in different scientific databases, such as Pubmed or Sciencedirect, among others, as well as in articles of scientific journals, books, doctoral theses and official web pages, always following previously established inclusion and exclusion criteria. Once the articles of interest had been selected using keywords, the contents of the review were organized.
Results: The conventional formulations used in antisepsis have some limitations, such as the formation of biofilms by methicillin-resistant Staphylococcus aureus (MRSA), the need to achieve a more prolonged effect over time and the potentiation of microbial activity due to resistance to antiseptics, among others. For this reason, there are several lines of research that attempt to counteract these barriers by designing new formulations such as self-emulsifying drug delivery systems (SEDDS), film-forming systems or using nanotechnology in the form of antiseptic-loaded micelles, mesoporous organosilica nanoparticles or as silver or ZnO nanoparticles that are combined with polymers such as hydrogels or polyurethanes to achieve more effective treatments by improving both their antiseptic and mechanical properties.
Conclusions: The different strategies discussed in this review present better antiseptic properties than conventional therapies, as reported in the articles reviewed. For this reason, they will surely be part of the wide range of antiseptics in the near future.
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References
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