Analytical and tecnological evaluation of an indomethacin cream.
Abstract
The physico-mechanical and chemical properties of a cream made in Cuba, which
contains indomethacin and methyl salicilate, were determined by doing control and
stability studies of the active ingredients and a technological evaluation of pharmacological
preparation.
A reversed-phase HPLC method, with UV detection is proposed. The analytical
column is a Spherisorb ODS-2, and the mobile phase is a mixture of acetonitrile and
acetic acid. Studies of linearity, accuracy and selectivity demonstrate the feasibility of
the proposed methodology.
For the technological evaluation penetration and extensibility assays and rheological
studies were performed.
The pharmacological preparation showed good stability, demonstrated by a triplicate
analysis of three lots of the cream in different storage conditions
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