Bone mineralization and bone alkaline phosphatase in newboms: relationships with maturity and fetal somatometry
Abstract
Bone mineral content (BMC) and bone mineral density (BMD) were measured by
dual energy X-ray densitometry, on the left femur of27 term and 44 premature appropiatefor-
gestational-age infants. Anthropometric measurements, serurn calcium and phosphorus
concentrations, and alkaline phosphatase activity were also evaluated. Premature infants
had lower serurn calcium and phosphorus concentrations (p<0.05), and higher alkaline
phosphatase activity (p<0.01) than term infants. Values ranged from 0.04 to 3.05 g for
BMC and from 0.26 to 0.81 glcm2 for BMD at birth. Premature infants had lower BMC
and BMD (p<0.01) than term infants. BMC correlated with serurn phosphorus (r=0.23),
alkaline phosphatase activity (r=-O.23), gestational age (r=0.78), weight (r=0.81), and length
(r=0.77). BMD correlated with gestional age (r=0.64), weight (r=0.61), and length (r=0.59).
The study emphasizes the significant effect of gestational age on the bone mineralization
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