Oxidative stress in the term newbom infant with respiratory distress treated with room oxygen
Abstract
We have studied the effects of oxygen administration to newborn infants older
than 35 weeks of gestational age suffering from respiratory distress due to Transient
Tachipnea (Group C) during their first three days of posnatallife. Following analytical
determinations have been made in whole peripheral blood: GSH, GSSG, quotient GSH/
GSSG, Superoxide Dismutase, Catalase, Glutathione Pero xi das e and Total Antioxidant
Capacity (T AC) measured as Trolox Equivalents. Presence of cellular damage has been
evaluated measuring intracellular enzymes such as ALT, AST, LDH and Creatinkinase.
Results obtained have been compared with a match group of normal newborn babies
before birth (Group A) and three days after birth (Group B). Results obtained show a
very significative tendency towards oxidative stress (GSH/GSSG quotient reduction)
caused just by the fetal-to-neonatal transition (A versus B); pro-oxidation is even
greater when newborns are receiving oxygen supplementations (A versus C). We have
found only a moderate response of antioxidant enzymes activity and of the T AC.
Newborn infants seem to have a delay in their adaptation to aereal lung respiration in
the first days after delivery and are especially to increments in the inspiratory fraction
of oxygen.
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