Arachidonic acid metabolites in CSF in the neonatal hypoxi-ischemic encephalopaty
Keywords:
Eicosanoids, Neonatal ischemiaAbstract
The preliminary results reported here suggest that perinatal asphyxia modifies the
synthesis of eicosanoids in the brain mainly the formation of TXB2. Therefre, it is
hypothesized that the major neonatal neuronalloss due to severe EHI is a result of both
the effects of hypoxia-ischemia and enhancement of the arachidonic acid pathway
during reperfusion. The imbalance between vaso active eiconsaoids may reduce FSC
with progression of neuronal death after asphyxia.
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